Proteins/UNIPROT:Q76N89

HECW1

ProteinUNIPROT:Q76N89

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS..

Function from UniProtKB (Q76N89), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 3 reference databases · Subject: HECW1 · Sources: gene ontology, Hetionet, Reactome

Order

CACNA1A interacts with HECW1ProteinHetionet hetionet:interacts:23072-773Inferred only
DVL1 interacts with HECW1ProteinHetionet hetionet:interacts:1855-23072Inferred only
HECW1 interacts with FBXL15ProteinHetionet hetionet:interacts:23072-79176Inferred only
GFI1B interacts with HECW1ProteinHetionet hetionet:interacts:23072-8328Inferred only
HECW1 interacts with RNF43ProteinHetionet hetionet:interacts:23072-54894Inferred only
SCNN1A interacts with HECW1ProteinHetionet hetionet:interacts:23072-6337Inferred only
SCNN1B interacts with HECW1ProteinHetionet hetionet:interacts:23072-6338Inferred only
SSR4 interacts with HECW1ProteinHetionet hetionet:interacts:23072-6748Inferred only
TP53 interacts with HECW1ProteinHetionet hetionet:interacts:23072-7157Inferred only
UBC interacts with HECW1ProteinHetionet hetionet:interacts:23072-7316Inferred only
USP7 interacts with HECW1ProteinHetionet hetionet:interacts:23072-7874Inferred only
HECW1 participates in Degradation of DVLPathwayReactome R-HSA-4641258Inferred only

Show the remaining 5

HECW1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
HECW1 participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
HECW1 participates in TCF dependent signaling in response to WNTPathwayReactome R-HSA-201681Inferred only
HECW1 regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology Q76N89|GO:0090090Inferred only
HECW1 regulates regulation of dendrite morphogenesisBiological processgene ontology Q76N89|GO:0048814Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

6 names

Resolves to: HECW1

Also called: HECT-type E3 ubiquitin transferase HECW1HECT, C2 and WW domain-containing protein 1hNEDL1KIAA0322NEDD4-like E3 ubiquitin-protein ligase 1NEDL1

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