Proteins/UNIPROT:O75369

FLNB

ProteinUNIPROT:O75369

Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.

Function from UniProtKB (O75369), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

7 rows

atelosteogenesis type I has a germline basis in FLNBDiseaseGenCC HGNC:3755|MONDO:0007167Inferred only
atelosteogenesis type III has a germline basis in FLNBDiseaseGenCC HGNC:3755|MONDO:0007168Inferred only
Boomerang dysplasia has a germline basis in FLNBDiseaseGenCC HGNC:3755|MONDO:0007208Inferred only
filamin-related bone disorder has a germline basis in FLNBDiseaseGenCC HGNC:3755|MONDO:0019690Inferred only
FLNB-associated autosomal dominant filamin related bone disorder has a germline basis in FLNBDiseaseGenCC HGNC:3755|MONDO:1060173Inferred only
Larsen syndrome has a germline basis in FLNBDiseaseGenCC HGNC:3755|MONDO:0007875Inferred only
spondylocarpotarsal synostosis syndrome has a germline basis in FLNBDiseaseGenCC HGNC:3755|MONDO:0010094Inferred only

Statements

51 statements

51 statements · 3 reference databases · Subject: FLNB · Sources: Hetionet, Reactome, WikiPathways

Order

ZBTB12 covaries with FLNBProteinHetionet hetionet:covaries:221527-2317Inferred only
FLNB covaries with ZDHHC8ProteinHetionet hetionet:covaries:2317-29801Inferred only
FLNB interacts with ASB2ProteinHetionet hetionet:interacts:2317-51676Inferred only
FLNB interacts with ATF7IPProteinHetionet hetionet:interacts:2317-55729Inferred only
CDK2 interacts with FLNBProteinHetionet hetionet:interacts:1017-2317Inferred only
CRK interacts with FLNBProteinHetionet hetionet:interacts:1398-2317Inferred only
DVL2 interacts with FLNBProteinHetionet hetionet:interacts:1856-2317Inferred only
ESR1 interacts with FLNBProteinHetionet hetionet:interacts:2099-2317Inferred only
FLNB interacts with FBLIM1ProteinHetionet hetionet:interacts:2317-54751Inferred only
FLNA interacts with FLNBProteinHetionet hetionet:interacts:2316-2317Inferred only
FLNB interacts with GP1BAProteinHetionet hetionet:interacts:2317-2811Inferred only
FLNB interacts with GRB2ProteinHetionet hetionet:interacts:2317-2885Inferred only

Show the remaining 39

FLNB interacts with ISG15ProteinHetionet hetionet:interacts:2317-9636Inferred only
FLNB interacts with ITGA4ProteinHetionet hetionet:interacts:2317-3676Inferred only
FLNB interacts with ITGB3ProteinHetionet hetionet:interacts:2317-3690Inferred only
FLNB interacts with ITGB6ProteinHetionet hetionet:interacts:2317-3694Inferred only
FLNB interacts with MAP3K1ProteinHetionet hetionet:interacts:2317-4214Inferred only
FLNB interacts with MAP3K4ProteinHetionet hetionet:interacts:2317-4216Inferred only
FLNB interacts with MAPK8ProteinHetionet hetionet:interacts:2317-5599Inferred only
FLNB interacts with MLH1ProteinHetionet hetionet:interacts:2317-4292Inferred only
FLNB interacts with MYBPC2ProteinHetionet hetionet:interacts:2317-4606Inferred only
FLNB interacts with NCK1ProteinHetionet hetionet:interacts:2317-4690Inferred only
FLNB interacts with NPHP1ProteinHetionet hetionet:interacts:2317-4867Inferred only
FLNB interacts with PIK3R1ProteinHetionet hetionet:interacts:2317-5295Inferred only
FLNB interacts with PLCG1ProteinHetionet hetionet:interacts:2317-5335Inferred only
FLNB interacts with PLEKHO1ProteinHetionet hetionet:interacts:2317-51177Inferred only
FLNB interacts with PSEN1ProteinHetionet hetionet:interacts:2317-5663Inferred only
FLNB interacts with PSEN2ProteinHetionet hetionet:interacts:2317-5664Inferred only
FLNB interacts with RAC1ProteinHetionet hetionet:interacts:2317-5879Inferred only
FLNB interacts with RAD21ProteinHetionet hetionet:interacts:2317-5885Inferred only
FLNB interacts with SIRT7ProteinHetionet hetionet:interacts:2317-51547Inferred only
FLNB interacts with SMURF2ProteinHetionet hetionet:interacts:2317-64750Inferred only
FLNB interacts with TSHRProteinHetionet hetionet:interacts:2317-7253Inferred only
FLNB interacts with UBCProteinHetionet hetionet:interacts:2317-7316Inferred only
FLNB interacts with VCAM1ProteinHetionet hetionet:interacts:2317-7412Inferred only
FLNB participates in Antimicrobial mechanism of IFN-stimulated genesPathwayReactome R-HSA-1169410Inferred only
FLNB participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
FLNB participates in Ebola virus infection in hostPathwayWikiPathways WP4217Inferred only
FLNB participates in Focal adhesionPathwayWikiPathways WP306Inferred only
FLNB participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
FLNB participates in Interferon SignalingPathwayReactome R-HSA-913531Inferred only
FLNB participates in ISG15 antiviral mechanismPathwayReactome R-HSA-1169408Inferred only
FLNB participates in MAPK signalingPathwayWikiPathways WP382Inferred only
FLNB participates in NPHP1 deletion syndromePathwayWikiPathways WP5399Inferred only
FLNB participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
LASP1 increases the expression of FLNBProteinHetionet hetionet:regulates:3927-2317Inferred only
OTUD7A decreases the expression of FLNBProteinHetionet hetionet:regulates:161725-2317Inferred only
RAB27A decreases the expression of FLNBProteinHetionet hetionet:regulates:5873-2317Inferred only
RBKS decreases the expression of FLNBProteinHetionet hetionet:regulates:64080-2317Inferred only
RNF125 decreases the expression of FLNBProteinHetionet hetionet:regulates:54941-2317Inferred only
USP20 decreases the expression of FLNBProteinHetionet hetionet:regulates:10868-2317Inferred only

Other names

15 names

Resolves to: FLNB

Also called: ABP-278ABP-280 homologActin-binding-like proteinBeta-filaminFh1Filamin homolog 1Filamin-3FLN-BFLN1LFLN3TABPTAPThyroid autoantigenTruncated ABPTruncated actin-binding protein

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