Fructose biosynthesis

The conversion of glucose to fructose via sorbitol was demonstrated by Hers (1960) in the seminal vesicles of sheep, has since been demonstrated as well in human epidydimal tissue, and appears to be the physiological source of the abundant fructose found in seminal fluid. The enzymes of the pathway are likewise abundant in the eye lens and in neurons, where their physiological role is less clear but where they appear to play a central role in diabetic tissue damage.

Summary from Reactome (R-HSA-5652227), read 2026-09-23.