What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- RDH5ProteinUNIPROT:Q92781substrate ofInferred only16 paths16 endpoints
- ADH4ProteinUNIPROT:P08319metabolized byInferred only14 paths14 endpoints
- RDH16ProteinUNIPROT:O75452substrate ofInferred only7 paths7 endpoints
- DHRS4ProteinUNIPROT:Q9BTZ2substrate ofInferred only7 paths7 endpoints
- HSD17B6ProteinUNIPROT:O14756substrate ofInferred only4 paths4 endpoints
- RLBP1ProteinUNIPROT:P12271substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
16 statements
16 statements · 1 reference database · Subject: 9-cis-retinal · Sources: Human-GEM
- 9-cis-retinol is converted to 9-cis-retinalCompoundHuman-GEM MAR20003Inferred only
- 9-cis-retinol is converted to 9-cis-retinalCompoundHuman-GEM MAR01690Inferred only
- 9-cis-retinol is converted to 9-cis-retinalCompoundHuman-GEM MAR06644Inferred only
- 9-cis-retinal is converted to 9-cis-retinolCompoundHuman-GEM MAR06644Inferred only
- 9-cis-retinal is converted to all-trans-retinalCompoundHuman-GEM MAR08702Inferred only
- all-trans-retinal is converted to 9-cis-retinalCompoundHuman-GEM MAR06650Inferred only
- all-trans-retinal is converted to 9-cis-retinalCompoundHuman-GEM MAR08702Inferred only
- 9-cis-retinal is metabolised by ADH4ProteinHuman-GEM MAR06644Inferred only
- 9-cis-retinal is a substrate of DHRS4ProteinHuman-GEM MAR06644Inferred only
- 9-cis-retinal is a substrate of DHRS4L2ProteinHuman-GEM MAR06644Inferred only
- 9-cis-retinal is a substrate of HSD17B6ProteinHuman-GEM MAR06644Inferred only
- 9-cis-retinal is a substrate of RBP3ProteinHuman-GEM MAR06644Inferred only
Show the remaining 4
- 9-cis-retinal is a substrate of RDH16ProteinHuman-GEM MAR06644Inferred only
- 9-cis-retinal is a substrate of RDH5ProteinHuman-GEM MAR06644Inferred only
- 9-cis-retinal is a substrate of RLBP1ProteinHuman-GEM MAR06644Inferred only
- 9-cis-retinal is a substrate of SDR16C5ProteinHuman-GEM MAR06644Inferred only
Reactions
13 reactions
9-cis-retinol+NADP(3-)9-cis-retinal+proton+NADPH(4-)
Catalysed by RDH11 or RDH8 or RDH12 or RDH13 or SDR16C5 or RDH14
Reaction pageLeft to rightBalancedEC 1.1.1.105GO:0005829
Human-GEM MAR01690CC BY 4.0Reference data
9-cis-retinal+proton+NADPH(4-)+dioxygenMAM01024c+water+NADP(3-)
Reaction pageLeft to rightBalancedEC 2.5.1.18GO:0005829
Human-GEM MAR02993CC BY 4.0Reference data
9-cis-retinal+proton+NADH(2-)9-cis-retinol+NAD(+)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or SDR16C5 or DHRS4L2 or ADH4 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105GO:0005829
Human-GEM MAR06644CC BY 4.0Reference data
all-trans-retinal9-cis-retinal
Reaction pageLeft to rightBalancedGO:0005783
Human-GEM MAR06650CC BY 4.0Reference data
9-cis-retinal+water+NAD(+)MAM01231r+2proton+NADH(2-)
Catalysed by ALDH1A2 or ALDH1A1
Reaction pageReversibleBalancedEC 1.2.1.36GO:0005783
Human-GEM MAR06652CC BY 4.0Reference data
9-cis-retinal+proton+NADPH(4-)+dioxygenMAM01023c+water+NADP(3-)
Catalysed by CYP1A2
Reaction pageLeft to rightBalancedEC 1.14.14.1GO:0005829
Human-GEM MAR06653CC BY 4.0Reference data
9-cis-retinal+proton+NADPH(4-)+dioxygenMAM01023r+water+NADP(3-)
Catalysed by CYP1A2
Reaction pageLeft to rightBalancedEC 1.14.14.1GO:0005783
Human-GEM MAR06654CC BY 4.0Reference data
9-cis-retinalall-trans-retinal
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR08702CC BY 4.0Reference data
9-cis-retinol+NAD(+)9-cis-retinal+proton+NADH(2-)
Catalysed by ADH4
Reaction pageLeft to rightBalancedEC 1.1.1.315GO:0005634
Human-GEM MAR20003CC BY 4.0Reference data
9-cis-retinol+NAD(1-)9-cis-retinal+NADH(2-)+hydron
Catalysed by RDH16 or ADH4 or ADH7 or RDH5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:42052CC BY 4.0Reference data
9-cis-retinal+NAD(1-)+waterCHEBI:78630+NADH(2-)+2hydron
Catalysed by ALDH1A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:42084CC BY 4.0Reference data
9-cis-retinol+NADP(3-)9-cis-retinal+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or AKR1B1 or AKR1C3 or RDH11 or RDH12 or RDH14
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:54916CC BY 4.0Reference data