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Proteins/UNIPROT:P16455
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Function from UniProtKB (P16455), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
61 statements
61 statements · 5 reference databases · Subject: MGMT · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
3 reactions
MAM00200c+MAM01719cMAM00216c+MAM01720c
Catalysed by MGMT
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.63cytosol
Human-GEM MAR09498CC BY 4.0Reference data
a 6-O-methyl-2'-deoxyguanosine in DNA+L-cysteinyl-[protein]S-methyl-L-cysteinyl-[protein]+a 2'-deoxyguanosine in DNA
Catalysed by MGMT
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24000CC BY 4.0Reference data
a 4-O-methyl-thymidine in DNA
2 names
Resolves to: MGMT
Catalysed by MGMT
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53428CC BY 4.0Reference data