a 2,3-dehydroacyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

138 compounds within 3 steps: 2 in 1, 10 in 2, 126 in 3

Three steps

prostaglandin H2Reach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS1 and 1 moreOne of 2 routes
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, TBXAS1 and 2 more
sarcosineReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by ACAD10, KDM1A, KDM1B, PIPOX
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
3. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)
Catalysed by ACAD10, MTO1, DHFR, DHFR2
2-oxo-3-sulfanylpropanoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-Cysteine:2-oxoglutarate aminotransferase
Catalysed by ACAD10, MOCOS, GOT2, GOT1cytosolOne of 3 routes
S-formylglutathioneReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. alcohol dehydrogenase (formaldehyde)
Catalysed by ACAD10, KDM1A, KDM1B, ADH1C and 5 morecytosol
L-methionineReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by ACAD10, AIFM1, PYROXD1, CDK5RAP1One of 10 routes
L-tryptophanReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and tryptophan (cytosol to extracellular)
Catalysed by ACAD10, MOCOS, SLC7A5extracellular space, cytosolOne of 4 routes
L-alanineReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by ACAD10, AIFM1, PYROXD1, SCLYOne of 17 routes
L-asparagineReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of asparagine and cysteine (cytosol to extracellular)
Catalysed by ACAD10, MOCOS, SLC7A5extracellular space, cytosolOne of 4 routes
L-phenylalanineReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and phenylalanine (cytosol to extracellular)
Catalysed by ACAD10, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes
gamma-L-glutamyl-L-cysteineReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)
Catalysed by ACAD10, MOCOS, GCLC, GCLMcytosolOne of 2 routes
S-sulfanyl-L-cysteineReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine
Catalysed by ACAD10, MOCOS, CARS2
phosphoenolpyruvateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
Catalysed by ACAD10, D2HGDH, PCK1, PCK2
N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (R)-4'-phosphopantothenate:L-cysteine ligase
Catalysed by ACAD10, MOCOS, PPCScytosolOne of 4 routes
3-sulfino-L-alanineReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-Cysteine:oxygen oxidoreductase
Catalysed by ACAD10, MOCOS, CDO1cytosolOne of 2 routes
an all-trans-retinyl esterReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. Lecithin Retinol Acyltransferase
Catalysed by ACAD10, RETSAT, LRATcytosolOne of 4 routes
all-trans-retinyl 9Z-octadecenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
Catalysed by ACAD10, RETSAT, PNPLA4, PNPLA2
di-(9Z)-octadecenoylglycerolReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
Catalysed by ACAD10, RETSAT, PNPLA4, PNPLA2
2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ACAD10, RETSAT, LRAT
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS1 and 1 more
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS1 and 1 more
9-cis-retinolReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol binding protein (retinol)
Catalysed by ACAD10, RETSAT, RBP1, RBP2cytosolOne of 2 routes
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
thio-Mo-molybdopterinReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, MOCOSOne of 3 routes
2-glyceryl-prostaglandin H2Reach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
prostaglandin H1Reach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS2
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by ACAD10, AIFM1, PYROXD1, PTGS1 and 1 more