7,8-dihydrofolate

Three steps

• dehydroepiandrosterone 3-sulfateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 1 morecytosol, extracellular space

• L-tryptophanReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 5 routes

• glutathioneReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by DHFR, DHFR2, SHMT1, GSScytosol

• L-alanineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of alanine and glycine (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC3A2 and 2 morecytosol, extracellular spaceOne of 6 routes

• leukotriene C4Reach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. leukotriene C4 hydrolysis

  Catalysed by DHFR, DHFR2, SHMT1cytosol

• L-asparagineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1cytosol, extracellular spaceOne of 4 routes

• L-phenylalanineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 7 routes

• adenosine 5'-phosphosulfateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. ATP:sulfate adenylyltransferase

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 2 morecytosol, extracellular spaceOne of 4 routes

• L-tyrosineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by DHFR, DHFR2, SHMT1, AADATcytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by DHFR, DHFR2, SHMT1, AGXT2cytosol

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by DHFR, DHFR2, ATIC, ADSLcytosolOne of 2 routes

• 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate

  Catalysed by DHFR, DHFR2, ATICcytosolOne of 3 routes

• N-formimidoyl-L-glutamateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
  3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

  Catalysed by DHFR, DHFR2, FTCDcytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by DHFR, DHFR2, SHMT1, GLYATL2cytosolOne of 2 routes

• estrone 3-sulfateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 1 morecytosol, extracellular space

• N-benzoylglycineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by DHFR, DHFR2, SHMT1cytosol, mitochondrial matrixOne of 2 routes

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 1 morecytosol, extracellular spaceOne of 2 routes

• dTMPReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase

  Catalysed by DHFR, DHFR2, SHMT1, TYMScytosolOne of 2 routes

• 3',3'-cGAMPReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

  Catalysed by DHFR, DHFR2, ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membrane

• (2S)-2-aminobutanoateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by DHFR, DHFR2, SHMT1, AGXT2cytosol

• glycodeoxycholateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by DHFR, DHFR2, SHMT1cytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by DHFR, DHFR2, SHMT1, GLYATL2cytosol

• N-eicosanoylglycinateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by DHFR, DHFR2, SHMT1, BAATcytosol

• N-docosanoylglycineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by DHFR, DHFR2, SHMT1, BAATcytosol

• N-hexacosanoylglycineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by DHFR, DHFR2, SHMT1, BAATcytosol