chlorine(.)

Three steps

• prostaglandin G1Reach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1

  Catalysed by SLC6A14, PTGS2extracellular space, cytosol, endoplasmic reticulum

• prostaglandin E3Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin E3 (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin H3Reach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS2extracellular space, cytosol

• 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC6A14, CYP3A4, CYP2C9extracellular space, cytosol, endoplasmic reticulum

• prostaglandin A2Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin A2 (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin B1Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin B1 (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO2A1extracellular space, cytosolOne of 2 routes

• prostaglandin J2Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and L-lactate (cytosol to extracellular)
  3. Transport of Prostaglandin J2, Lactate Antiport

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

• 15-oxoprostaglandin F2alphaReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and L-lactate (cytosol to extracellular)
  3. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

• leukotriene F4Reach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and leukotriene F4 (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSSextracellular space, cytosolOne of 4 routes

• epsilon-(gamma-L-glutamyl)-L-lysineReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)
  3. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

  Catalysed by SLC6A14, SLC7A9, SLC25A29, SLC7A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• prostaglandin A2-S-(R)-glutathioneReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

  Catalysed by SLC6A9, SLC6A14, GSS, GSTA1 and 1 moreextracellular space, cytosol

• prostaglandin A2-S-(S)-glutathioneReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

  Catalysed by SLC6A9, SLC6A14, GSS, GSTP1 and 1 moreextracellular space, cytosol

• prostaglandin J2-S-(R)-glutathioneReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

  Catalysed by SLC6A9, SLC6A14, GSS, GSTA1 and 2 moreextracellular space, cytosol

• prostaglandin J2-S-(S)-glutathioneReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

  Catalysed by SLC6A9, SLC6A14, GSS, GSTP1 and 1 moreextracellular space, cytosol

• 13-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS2extracellular space, cytosol

• 9-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS2extracellular space, cytosol

• (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

  Catalysed by SLC6A14, ALOX15extracellular space, cytosol, endoplasmic reticulum

• (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

  Catalysed by SLC6A14, ALOX15extracellular space, cytosol, endoplasmic reticulum

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLC6A6, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosol, peroxisomeOne of 35 routes

• all-trans-4-hydroxyretinoateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and retinoate (cytosol to extracellular)
  3. cytochrome P450 (retinoate)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, CYP26A1extracellular space, cytosolOne of 3 routes

• N-acetylcadaverineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of acetate and formate (cytosol to extracellular)
  3. N-acetylcadaverine + H2O = cadaverine + acetate

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A1 and 1 moreextracellular space, cytosol

• 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by SLC6A14, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by SLC6A14, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC6A14, CYP2C9extracellular space, cytosol, endoplasmic reticulum

• (13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS1, PTGS2extracellular space, cytosol

• 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by SLC6A14, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosol, endoplasmic reticulum

• (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

  Catalysed by SLC6A9, SLC6A14, GSS, GSTM4 and 1 moreextracellular space, cytosol

• 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS2extracellular space, cytosol

• 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS2extracellular space, cytosol

• 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS2extracellular space, cytosol

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazoleReach from here →
  1. Transport of L-Glutamine by Atb0 Transporter
  2. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)
  3. 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)

  Catalysed by SLC6A14, PFAS, GARTextracellular space, cytosol

• 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS2extracellular space, cytosol

• 2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by SLC6A6, MTO1, PTGS2extracellular space, cytosol

• N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)
  3. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

  Catalysed by SLC6A14, GGTLC3, GGT1, GGT5 and 4 moreextracellular space, cytosol

• all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and retinoate (cytosol to extracellular)
  3. glucuronosyltransferase (retinoate)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, UGT1A1 and 2 moreextracellular space, cytosol, endoplasmic reticulum

• all-trans-18-hydroxyretinoateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and retinoate (cytosol to extracellular)
  3. unspecific monooxygenase (retinoate)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, CYP1A1 and 24 moreextracellular space, cytosolOne of 2 routes

• a phenyl acetateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of acetate and formate (cytosol to extracellular)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A1 and 3 moreextracellular space, cytosol

• 3-sulfinopyruvateReach from here →
  1. transport of chloride and cysteine (cytosol to extracellular)
  2. L-Cysteine:oxygen oxidoreductase
  3. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase

  Catalysed by SLC6A14, CDO1, GOT1extracellular space, cytosolOne of 2 routes

• S-methyl glutathioneReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by SLC6A9, SLC6A14, GSS, MMACHCextracellular space, cytosol

• N-octanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

  Catalysed by SLC6A9, SLC6A14, AADAT, PAMextracellular space, cytosolOne of 2 routes

• N-decanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate

  Catalysed by SLC6A9, SLC6A14, AADAT, PAMextracellular space, cytosolOne of 2 routes

• N-dodecanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

  Catalysed by SLC6A9, SLC6A14, AADAT, PAMextracellular space, cytosolOne of 2 routes

• N-tetradecanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate

  Catalysed by SLC6A9, SLC6A14, AADAT, PAMextracellular space, cytosolOne of 2 routes

• N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate

  Catalysed by SLC6A9, SLC6A14, AADAT, PAMextracellular space, cytosolOne of 2 routes

• N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by SLC6A9, SLC6A14, AADAT, PAMextracellular space, cytosol

• D-histidineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. taurine + L-arginine = taurocyamine + L-ornithine
  3. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by SLC6A6, GATM, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• indoxyl sulfateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. indoxyl sulfate(out) + a dicarboxylate(in) = indoxyl sulfate(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactoneReach from here →
  1. Transport of L-Glutamine by Atb0 Transporter
  2. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
  3. D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + NADPH + 2 H(+)

  Catalysed by SLC6A14, GFPT2, GFPT1, H6PDextracellular space, cytosol

• 2,3-didehydrophenylalanineReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC6A9, SLC6A14, DPEP1extracellular space, cytosol

• S-adenosylglutathioneReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by SLC6A9, SLC6A14, GSS, MMACHCextracellular space, cytosol