K(+)

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

458 compounds within 3 steps: 5 in 1, 61 in 2, 392 in 3

Two steps

2-oxo-3-sulfanylpropanoateReach from here →
1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
2. L-Cysteine:2-oxoglutarate aminotransferase
Catalysed by SLC1A1, GOT2, GOT1inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes
L-methionineReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membraneOne of 8 routes
L-tryptophanReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membraneOne of 6 routes
beta-alanineReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
L-alanineReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. oxaloacetate + L-alanine = L-aspartate + pyruvate
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membraneOne of 15 routes
L-asparagineReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, cytosolOne of 6 routes
N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane
L-phenylalanineReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membraneOne of 8 routes
gamma-L-glutamyl-L-cysteineReach from here →
1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
2. L-glutamate:L-cysteine gamma-ligase (ADP-forming)
Catalysed by SLC1A1, GCLC, GCLMinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
L-tyrosineReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane
(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
S-sulfanyl-L-cysteineReach from here →
1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
2. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine
Catalysed by SLC1A1, CARS2inner side of the membrane, outer side of the membrane
N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
2. (R)-4'-phosphopantothenate:L-cysteine ligase
Catalysed by SLC1A1, PPCSinner side of the membrane, outer side of the membrane, cytosolOne of 4 routes
3-sulfino-L-alanineReach from here →
1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 6 routes
thio-Mo-molybdopterinReach from here →
1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by SLC1A1, MOCOSinner side of the membrane, outer side of the membrane

Three steps

beta-carbolineReach from here →
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, cytosol
(S)-carnitineReach from here →