3-mercaptolactic acid

Three steps

• a quinolReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 2 morecytosol

• N-acetyl-L-cysteineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  3. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• K(+)Reach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• a thiolReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 2 morecytosol

• chlorine(.)Reach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol, extracellular spaceOne of 2 routes

• acetateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 7 morecytosol, extracellular spaceOne of 2 routes

• formic acidReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 7 morecytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 8 morecytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 8 morecytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosolOne of 2 routes

• glutarateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-oxopropanoateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. De novo synthesis of 2Fe2S

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 9 morecytosol, mitochondrial matrix

• D-serineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• (R)-lactic acidReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• (S)-lactic acidReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 2 morecytosol, mitochondrial matrixOne of 5 routes

• 2-iminopropanoateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• phosphoenolpyruvic acidReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. pyruvate kinase (dTDP)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 4 morecytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• L-ornithineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol, extracellular spaceOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• glycineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 5 morecytosol, extracellular spaceOne of 4 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• L-methionineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. transport of cysteine and methionine (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol, extracellular spaceOne of 7 routes

• L-tryptophanReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol, extracellular spaceOne of 4 routes

• glutathioneReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 2 morecytosol

• L-alanineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. transport of alanine and cysteine (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol, extracellular spaceOne of 32 routes

• L-asparagineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol, extracellular spaceOne of 4 routes

• L-phenylalanineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol, extracellular spaceOne of 6 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 4 morecytosolOne of 2 routes

• glutathione disulfideReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• S-sulfanyl-L-cysteineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• (3S)-citramalyl-CoAReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• 5-amino-2-oxopentanoateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• S-sulfanylglutathioneReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. thiosulfate + glutathione = S-sulfanylglutathione + sulfite + H(+)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosolOne of 4 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosolOne of 4 routes

• 3-sulfino-L-alanineReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosolOne of 2 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• ubiquinol-10Reach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 2 morecytosolOne of 2 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• thio-Mo-molybdopterinReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 3 morecytosol

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. 3-Mercaptolactate:NAD+ oxidoreductase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by LDHB, LDHC, LDHAL6A, LDHAL6B and 5 morecytosol, mitochondrial matrix