a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine

Three steps

• an N-acylsphinganineReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphingosine N-acyltransferase (sphinganine)

  Catalysed by GBA1, GALC, GBA3, GBA2 and 10 moreGolgi apparatus, cytosolOne of 3 routes

• an N-acyl-(4R)-4-hydroxysphinganineReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by GBA1, GALC, GBA3, GBA2 and 2 moreGolgi apparatus

• eicosanoateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. N-Acylsphingosine amidohydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 morelysosome, extracellular spaceOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. N-Acylsphingosine amidohydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 morelysosome, extracellular spaceOne of 12 routes

• (15Z)-tetracosenoateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. N-Acylsphingosine amidohydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 morelysosome, extracellular spaceOne of 12 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. N-Acylsphingosine amidohydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 morelysosome, extracellular spaceOne of 12 routes

• (11Z)-eicosenoateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. N-Acylsphingosine amidohydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 morelysosome, extracellular spaceOne of 12 routes

• thiosulfateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + 3'-phosphoadenylyl sulfate = an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
  2. Sulfatide sulfohydrolase
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by GAL3ST1, ARSA, ARSD, ARSL and 4 morelysosome, inner side of the membrane, outer side of the membraneOne of 2 routes

• (24S)-hydroxycholesterolReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 more

• a fatty aldehydeReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid
  3. a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)

  Catalysed by GBA1, GALC, GBA3, GBA2 and 7 more

• cholesteryl hexadecanoateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 more

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by GBA1, GALC, GBA3, GBA2 and 8 moreGolgi apparatus, cytosol

• sphingosine 1-phosphateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. ATP:sphingosine 1-phosphotransferase

  Catalysed by GBA1, GALC, GBA3, GBA2 and 7 moreGolgi apparatus, cytosolOne of 2 routes

• cholesteryl (9Z,12Z)-octadecadienoateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. (9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 moreOne of 2 routes

• D-glucoseReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. UDP-glucose:N-acylsphingosine D-glucosyltransferase
  3. D-Glucosyl-N-acylsphingosine glucohydrolase

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 morecytosolOne of 5 routes

• 25-hydroxycholesterolReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 moreOne of 3 routes

• N-octanoylsphing-4-enineReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside

  Catalysed by GBA1, GALC, GBA3, GBA2

• cholesteryl (9Z-octadecenoate)Reach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 2 moreOne of 2 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)

  Catalysed by GBA1, GALC, GBA3, GBA2 and 5 moreGolgi apparatusOne of 2 routes

• a 1,3-diacylglycerolReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 6 moreGolgi apparatus

• a 1,2-diacylglycerolReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 9 moreGolgi apparatusOne of 2 routes

• (24R)-hydroxycholesterolReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24R)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 more

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 7 moreGolgi apparatus

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GALC, GBA3, GBA2 and 4 moreGolgi apparatus, cytosol

• dodecanoyl-CoAReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GALC, GBA3, GBA2 and 4 moreGolgi apparatus, cytosol

• eicosanoyl-CoAReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GALC, GBA3, GBA2 and 4 moreGolgi apparatus, cytosol

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GALC, GBA3, GBA2 and 4 moreGolgi apparatus, cytosol

• tetradecanoyl-CoAReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GALC, GBA3, GBA2 and 4 moreGolgi apparatus, cytosol

• octadecanoyl-CoAReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GALC, GBA3, GBA2 and 4 moreGolgi apparatus, cytosol

• a 1-acylglycerone 3-phosphateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 5 moreGolgi apparatus

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 5 moreGolgi apparatusOne of 9 routes

• an N-acylglycineReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by GBA1, GALC, GBA3, GBA2 and 7 moreGolgi apparatus

• CMP-N-acetyl-beta-neuraminateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = a ganglioside GM4 (d18:1(4E)) + CMP + H(+)
  2. Acylneuraminyl hydrolase
  3. CTP:N-acetylneuraminate cytidylyltransferase

  Catalysed by ST3GAL5, NEU4, NEU1, NEU3 and 2 morelysosome, nucleusOne of 3 routes

• N-sulfo-D-glucosamineReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + 3'-phosphoadenylyl sulfate = an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
  2. Sulfatide sulfohydrolase
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by GAL3ST1, ARSA, ARSD, ARSL and 1 morelysosome

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 6 moreGolgi apparatus

• dehydroepiandrosterone 3-sulfateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + 3'-phosphoadenylyl sulfate = an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
  2. Sulfatide sulfohydrolase
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by GAL3ST1, ARSA, ARSD, ARSL and 1 morelysosome

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 8 moreGolgi apparatus

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)Reach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• adenosine 5'-phosphosulfateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + 3'-phosphoadenylyl sulfate = an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
  2. Sulfatide sulfohydrolase
  3. ATP:sulfate adenylyltransferase

  Catalysed by GAL3ST1, ARSA, ARSD, ARSL and 2 morelysosome, cytosolOne of 4 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)Reach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)

  Catalysed by GBA1, GALC, GBA3, GBA2 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. N-Acylsphingosine amidohydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GBA1, GALC, GBA3, GBA2 and 1 morelysosome, extracellular spaceOne of 12 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 17 moreGolgi apparatusOne of 2 routes

• estrone 3-sulfateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + 3'-phosphoadenylyl sulfate = an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
  2. Sulfatide sulfohydrolase
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by GAL3ST1, ARSA, ARSD, ARSL and 1 morelysosome

• sphing-4-enine 1-phosphateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + ATP = sphing-4-enine 1-phosphate + ADP + H(+)

  Catalysed by GBA1, GALC, GBA3, GBA2 and 6 moreGolgi apparatus

• (9Z)-hexadecenoyl-CoAReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GALC, GBA3, GBA2 and 4 moreGolgi apparatus, cytosol

• a cardiolipinReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 5 moreGolgi apparatus

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + 3'-phosphoadenylyl sulfate = an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
  2. Sulfatide sulfohydrolase
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by GAL3ST1, ARSA, ARSD, ARSL and 1 morelysosome, extracellular space, cytosolOne of 2 routes

• an all-trans-retinyl esterReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by GBA1, GALC, GBA3, GBA2 and 8 moreGolgi apparatusOne of 2 routes

• CHEBI:63544Reach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GBA1, GALC, GBA3, GBA2 and 4 moreGolgi apparatus, cytosol

• 1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →
  1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)

  Catalysed by GBA1, GALC, GBA3, GBA2 and 5 moreGolgi apparatus