dehydroascorbic acid

Three steps

• prostaglandin D2Reach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 3 routes

• leukotriene A4Reach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

• (R)-S-lactoylglutathioneReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosolOne of 3 routes

• S-formylglutathioneReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosolOne of 2 routes

• L-alanineReach from here →
  1. 7-hydroperoxy-H4-neuroprostane to 7-hydroxy-E4-neuroprostane conversion
  2. cytochrome b reductase (ascorbate)
  3. De novo synthesis of 2Fe2S

  Catalysed by CYBRD1, NDUFAB1, FDXR, FXN and 4 morecytosol, extracellular space, mitochondrial matrixOne of 2 routes

• leukotriene C4Reach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. leukotriene C4 synthase (GSH)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 5 routes

• taurolithocholate 3-sulfateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

• 5-oxo-L-prolineReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by GSR, CHAC2, CHAC1cytosol

• histamineReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

• L-thyroxineReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

• S-sulfanylglutathioneReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, mitochondrial matrixOne of 6 routes

• dopamineReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

• heme bReach from here →
  1. 7-hydroperoxy-H4-neuroprostane to 7-hydroxy-E4-neuroprostane conversion
  2. cytochrome b reductase (ascorbate)
  3. Ferrochelatase, Mitochondrial

  Catalysed by CYBRD1, FECHcytosol, extracellular space, mitochondrial matrixOne of 3 routes

• prostaglandin E2Reach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

• L-cysteinylglycineReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosolOne of 6 routes

• ubiquinol-10Reach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by GSR, SQORcytosol

• (R)-adrenalineReach from here →
  1. 7-hydroperoxy-H4-neuroprostane to 7-hydroxy-E4-neuroprostane conversion
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

  Catalysed by DBH, PNMTcytosol

• CHEBI:730073Reach from here →
  1. 7-hydroperoxy-H4-neuroprostane to 7-hydroxy-E4-neuroprostane conversion
  2. ascorbate to monodehydroascorbate conversion
  3. Peroxidase

  Catalysed by MPOcytosol, nucleusOne of 3 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by GSR, GPX1, GPX4cytosol

• ursodeoxycholateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin G2Reach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

• glycodeoxycholateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GSR, ABCC4cytosol, inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GSR, GPX1, GPX2, GPX4cytosol

• N-tetradecanoylglycineReach from here →
  1. 7-hydroperoxy-H4-neuroprostane to 7-hydroxy-E4-neuroprostane conversion
  2. 8-peroxy-(5Z,9E,11Z,14Z)... to 5,9-cyclo-6,8-cycloperoxy-12... conversion
  3. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by PAMcytosol

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GSR, PTGES, MGST3, GPX1 and 3 morecytosol

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GSR, GPX1, GPX4cytosol

• thromboxane B2Reach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

• an S-substituted glutathioneReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by GSR, GSTT4, GSTA4, GSTZ1 and 20 morecytosolOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by GSR, GPX1, GSTA1, GPX2 and 1 morecytosol

• taurochenodeoxycholateReach from here →
  1. glutathione:dehydroascorbate oxidoreductase
  2. Glutathione: 15-HPETE oxidoreductase
  3. solute carrier organic anion transporter (GSH)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol, extracellular spaceOne of 3 routes