itaconate

Three steps

• tetradecanoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by SUCLG1, SUCLG2, SUCLA2, CROTmitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. phytanate-CoA ligase

  Catalysed by SUCLG1, SUCLG2, SUCLA2mitochondrial matrix, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 6 moremitochondrial matrix, cytosolOne of 15 routes

• 15-oxoprostaglandin E2Reach from here →
  1. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  2. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)
  3. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

  Catalysed by SUGCT, SLC22A8, HPGDinner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin H2Reach from here →
  1. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  2. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)
  3. prostaglandin E synthase (prostaglandin E2)

  Catalysed by SUGCT, SLC22A8, PTGES, PTGES3 and 1 moreinner side of the membrane, outer side of the membrane, endoplasmic reticulumOne of 4 routes

• prostaglandin D2Reach from here →
  1. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  2. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)
  3. aldo-keto reductase (prostaglandin D2)

  Catalysed by SUGCT, SLC22A8, AKR1C3inner side of the membrane, outer side of the membrane, cytosol

• O-acetyl-(R)-carnitineReach from here →
  1. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. (R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA

  Catalysed by SUGCT, SLC22A8, CRATinner side of the membrane, outer side of the membraneOne of 3 routes

• sphing-4-enineReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SUCLG1, SUCLG2, SUCLA2, ASAH1 and 3 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SAT1 and 1 moremitochondrial matrix, cytosolOne of 3 routes

• L-methionineReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, NAGSmitochondrial matrix

• glutathioneReach from here →
  1. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  2. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)
  3. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SUGCT, SLC22A24, SLC22A8, ABCC4inner side of the membrane, outer side of the membraneOne of 3 routes

• L-alanineReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by SUCLG1, SUCLG2, SUCLA2mitochondrial matrix

• L-asparagineReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, NAGSmitochondrial matrix

• L,L-cystathionineReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, NAGSmitochondrial matrix

• an acyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SUCLG1, SUCLG2, SUCLA2, ASAH1 and 3 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, HADHA and 2 moremitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 1 moremitochondrial matrix, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 1 moremitochondrial matrix, cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 1 moremitochondrial matrix, cytosol

• CHEBI:63544Reach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 8 routes

• CHEBI:730073Reach from here →
  1. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. Peroxidase

  Catalysed by SUGCT, SLC22A8, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. Activation of dodecanedioic acid

  Catalysed by SUCLG1, SUCLG2, SUCLA2mitochondrial matrix, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. Production of Sebacoylcarnitine

  Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)
  3. Production of Suberylcarnitine

  Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 4 routes