sn-glycerol 3-phosphocholine

Three steps

• (3Z)-dodecenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by GPCPD1, CHAT, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
  3. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by GDPD5, GPCPD1, GPAT3, GPAT2 and 13 moreOne of 2 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by GPCPD1, CHAT, SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by GPCPD1, CHAT, SLC27A2, SLC27A5cytosolOne of 4 routes

• D-glyceraldehyde 3-phosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  3. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate

  Catalysed by GDPD5, GPCPD1, GPD1, GPD1L and 1 moreOne of 2 routes

• 4-aminobutanoateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC6A12cytosol, extracellular spaceOne of 4 routes

• L-prolineReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by GDPD5, GPCPD1, GPD2, PRODH and 1 more

• decanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by GPCPD1, CHAT, ACSM4, ACSM1 and 4 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by GPCPD1, CHAT, CPT1A, CPT1C and 1 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by GPCPD1, CHAT, CPT1A, CPT1Bcytosol

• CHEBI:63544Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• a 1-acyl-sn-glycerolReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
  3. a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate

  Catalysed by GDPD5, GPCPD1, GPAT3, GPAT2 and 4 more

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate

  Catalysed by GDPD5, GPCPD1, PGS1, PTPMT1

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by GPCPD1, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 2 routes

• 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
  3. a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate

  Catalysed by GDPD5, GPCPD1, GPAT3, GPAT2 and 3 more

• 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
  3. a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GDPD5, GPCPD1, GPAT3, GPAT2 and 3 more

• hexacosanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• a 2,3-saturated acyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by GPCPD1, CHDH, ACAD10cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by GPCPD1, CHAT, CPT1A, CPT1C and 1 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• D-ribulose 1-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. L-xylulose 1-phosphate glycolaldehyde-lyase (glycerone-phosphate-forming)

  Catalysed by GPCPD1, GPD2, ALDOA, ALDOB and 1 morecytosol, mitochondrial matrix

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GPCPD1, GPAT3, GPAT2, GPAT4 and 2 morecytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GPCPD1, GPAT3, GPAT2, GPAT4 and 2 morecytosol

• 1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GPCPD1, GPAT3, GPAT2, GPAT4 and 2 morecytosol

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by GPCPD1, GPAT3, GPAT2, GPAT4 and 3 morecytosol

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  2. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)

  Catalysed by ENPP6, PCYT1A, PCYT1B, CHPT1 and 1 more

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA

  Catalysed by GPCPD1, GPAT3, GPAT2, GPAT4 and 2 morecytosol

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by GDPD5, GPCPD1, GPAT3, GPAT4 and 10 more

• 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (linoleoyl-CoA)
  3. 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GPCPD1, GPAT3, GPAT2, GPAT4 and 2 morecytosol

• 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GDPD5, GPCPD1, GPAT3, GPAT4 and 7 more

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GDPD5, GPCPD1, GPAT3, GPAT4 and 6 more

• 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  3. heptadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GDPD5, GPCPD1, GPAT3, GPAT4 and 6 more