CHEBI:15650

Three steps

• octadecan-1-olReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 2 NADPH + 2 H(+) = octadecan-1-ol + 2 NADP(+) + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 37 morecytosol

• eicosanoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. Eicosanoyl-CoA hydrolase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 39 morecytosolOne of 4 routes

• (9Z)-hexadecenoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, endoplasmic reticulumOne of 8 routes

• (15Z)-tetracosenoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)
  3. (15Z)-tetracosenoyl-CoA hydrolase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 38 morecytosol

• (11Z)-eicosenoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
  3. (11Z)-eicosenoyl-CoA hydrolase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 39 morecytosol

• putrescineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 3 routes

• methylarsonateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by SLCO1B1, GPX5, GPX1, GPX2 and 8 moreextracellular space, cytosol

• thiosulfateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLCO1B1, GPX5, GPX1, GPX2 and 7 moreextracellular space, cytosolOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, mitochondrial matrix

• di-mu-sulfido-diiron(2+)Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. De novo synthesis of 2Fe2S

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosol, mitochondrial matrix

• D-cysteineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 6 routes

• an acylcholineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Acetyl-CoA:choline O-acetyltransferase
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, nucleus

• fatty acidReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (elaidate)
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 8 routes

• 5-aminolevulinateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, mitochondrial matrix

• glycochenodeoxycholateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrix

• taurodeoxycholateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 4 routes

• glycochenodeoxycholic acidReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, peroxisomeOne of 5 routes

• cholesteryl hexadecanoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Palmitate:CoA ligase (AMP-forming)
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 38 morecytosol, endoplasmic reticulum

• glyoxylateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrixOne of 11 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, Golgi apparatus

• CHEBI:36882Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Itaconate:CoA ligase (GDP-forming)
  3. (3S)-citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrix

• 3-hydroxyisovaleric acidReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)
  3. Formation of 3-Hydroxy-Isovalerate

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, mitochondrial matrix

• 3,7,11,15-tetramethylhexadecanoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. phytanate-CoA ligase
  3. peroxisomal acyl-CoA thioesterase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, peroxisomeOne of 3 routes

• sphingosine 1-phosphateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. ATP:sphingosine 1-phosphotransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 35 morecytosol, Golgi apparatusOne of 2 routes

• CHEBI:37946Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. aryl sulfotransferase (dopamine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 3 moreextracellular space, cytosol

• L-2-amino-3-oxobutanoic acidReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrix

• cholesteryl (9Z,12Z)-octadecadienoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 38 morecytosol, endoplasmic reticulumOne of 2 routes

• (R)-lactic acidReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-Lactoylglutathione hydrolase

  Catalysed by SLCO1B1, GLO1, GLOD4, HAGH and 1 moreextracellular space, cytosolOne of 2 routes

• (S)-lactic acidReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin A2 (cytosol to extracellular)
  3. Transport of Prostaglandin A2, Lactate Antiport

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Production of Glutaryl Carnitine
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol

• phosphoenolpyruvic acidReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. ATP citrate lyase (citrate)
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosolOne of 2 routes

• 13-cis-retinolReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol = 13-cis-retinol

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 34 morecytosol

• spermineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = spermine + S-methyl-5'-thioadenosine + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 2 routes

• cholesteryl (9Z-octadecenoate)Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, endoplasmic reticulum

• L-ornithineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosolOne of 15 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, Golgi apparatusOne of 2 routes

• a 1,3-diacylglycerolReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 34 morecytosol, Golgi apparatus

• N-methylserotoninReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, INMTextracellular space, cytosol

• a 1,2-diacylglycerolReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 37 morecytosol, Golgi apparatusOne of 2 routes

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 5-Hydroxytryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MAOA and 1 moreextracellular space, cytosolOne of 2 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, mitochondrial matrix

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by SLCO1B1, FAAHextracellular space, cytosol

• an N-acylsphing-4-enineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 38 morecytosol, Golgi apparatus

• N-tetracosanoylsphinganineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. tetracosanoyl-CoA + sphinganine = N-tetracosanoylsphinganine + CoA + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 39 morecytosol

• N-hexacosanoylsphinganineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + sphinganine = N-hexacosanoylsphinganine + CoA + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 39 morecytosol

• malonaldehydeReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  3. thromboxane A synthase (12(S)-HHT)

  Catalysed by SLCO1B1, SLCO2A1, TBXAS1extracellular space, cytosolOne of 2 routes

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 1 moreextracellular space, cytosol

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 34 morecytosol, Golgi apparatus

• succinyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)
  3. (R)-methylmalonyl-CoA = succinyl-CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, mitochondrial matrixOne of 3 routes