N-(9Z,12Z-octadecadienoyl)-glycine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

532 compounds within 3 steps: 2 in 1, 102 in 2, 428 in 3

Three steps

a 1,3-diacyl-sn-glycerolReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. acyl-CoA pool formation and breakdown
3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA
Catalysed by GLYATL2, MOGAT1cytosolOne of 2 routes
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. acyl-CoA pool formation and breakdown
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
Catalysed by GLYATL2, LPCAT2, LPCAT1cytosol
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. acyl-CoA pool formation and breakdown
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by GLYATL2, LPCAT4cytosol
1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. Beta Oxidation of Fatty Acid
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by GLYATL2, ACADM, ACADS, LPCAT4mitochondrial matrix
undecanoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. bile acid-CoA: amino acid N-acyltransferase
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by GLYATL2, BAAT, ACSM4, ACSM1 and 4 moreperoxisome, cytosolOne of 3 routes
a fatty acyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
Catalysed by GLYATL2
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
Catalysed by GLYATL2, GSS, GPX1, GPX4One of 2 routes
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)
3. (9Z,12Z)-octadecadienoate + reduced [NADPH--hemoprotein reductase] + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by GLYATL2, ACOT8, ACOT2, THEM5 and 2 moreOne of 2 routes
ursodeoxycholateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and ursodeoxycholate (cytosol to extracellular)
Catalysed by GLYATL2, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
hexadecanoateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
Catalysed by GLYATL2, LPCAT3, MBOAT2, LPCAT1 and 2 more
prostaglandin G2Reach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and prostaglandin G2 (cytosol to extracellular)
Catalysed by GLYATL2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes
thio-Mo-molybdopterinReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. transport of cysteine and glycine (cytosol to extracellular)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A8 and 1 moreextracellular space, cytosol
(24S)-hydroxycholesterol 3-linoleoateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
3. (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by GLYATL2, LPCAT3, MBOAT2, LPCAT1 and 1 more
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by GLYATL2, GSS, GPX1, GPX2 and 1 more
1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerolReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA
3. 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)
Catalysed by GLYATL2, HADHA, PLA2G6, PNPLA8
1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserineReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)
3. 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + (9Z,12Z)-octadecadienoate + H(+)
Catalysed by GLYATL2, ACOT8, ACOT2, THEM5 and 2 more
(5Z)-tetradecenoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by GLYATL2, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 9 routes
(3E)-decenoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. bile acid-CoA: amino acid N-acyltransferase
3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by GLYATL2, BAAT, ACADM, ECHS1 and 2 moreperoxisome, mitochondrial matrix
1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
3. 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
Catalysed by GLYATL2, AGPAT4, CDS2, CDS1
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. bile acid-CoA: amino acid N-acyltransferase
3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by GLYATL2, BAAT, HADHA, ACAA2 and 1 moreperoxisome, mitochondrial matrix
an N(2)-acyl-L-glutamineReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. transport of glutamine and glycine (cytosol to extracellular)
3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
Catalysed by GLYATL2, SLC7A5, GLYATL1B, GLYATL1extracellular space, cytosolOne of 2 routes
(7Z)-hexadecenoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by GLYATL2, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 9 routes
3-methylmalateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
Catalysed by GLYATL2, AADAT, CLYBL
tricosanoyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by GLYATL2, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by GLYATL2, GSS, PTGES, MGST3 and 4 more
(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by GLYATL2, GSS, GPX1, GPX4
thromboxane B2Reach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and thromboxane B2 (cytosol to extracellular)
Catalysed by GLYATL2, GSS, SLCO1B1cytosol, extracellular spaceOne of 2 routes
a 3-oxoacyl-CoAReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. acyl-CoA pool formation and breakdown
3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
Catalysed by GLYATL2, ACAA1, SCP2, ACAA2 and 1 morecytosol
an S-substituted glutathioneReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
Catalysed by GLYATL2, GSS, GSTT4, GSTA4 and 21 moreOne of 2 routes
13-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)
3. (9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate
Catalysed by GLYATL2, ACOT8, ACOT2, THEM5 and 2 more
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
Catalysed by GLYATL2, GSS, GPX1, GSTA1 and 2 moreOne of 2 routes
taurochenodeoxycholateReach from here →
1. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. solute carrier organic anion transporter (GSH)
Catalysed by GLYATL2, GSS, SLCO1A2, SLC7A9 and 1 morecytosol, extracellular spaceOne of 3 routes