Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P61163

ACTR1A

Protein·UNIPROT:P61163

Open in the graph

Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules..

Function from UniProtKB (P61163), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

52 statements

52 statements · 3 reference databases · Subject: ACTR1A · Sources: Hetionet, Reactome, WikiPathways

Search this listOrder

ACTR1A interacts with ACTR10ProteinHetionet hetionet:interacts:10121-55860Inferred only
ACTR1A interacts with COPS5ProteinHetionet hetionet:interacts:10121-10987Inferred only
CUL1 interacts with ACTR1AProteinHetionet hetionet:interacts:10121-8454Inferred only
CUL3 interacts with ACTR1AProteinHetionet hetionet:interacts:10121-8452Inferred only
DCTN1 interacts with ACTR1AProteinHetionet hetionet:interacts:10121-1639Inferred only
ACTR1A interacts with DCTN4ProteinHetionet hetionet:interacts:10121-51164Inferred only
NUMA1 interacts with ACTR1AProteinHetionet hetionet:interacts:10121-4926Inferred only
PCLAF interacts with ACTR1AProteinHetionet hetionet:interacts:10121-9768Inferred only
ACTR1A interacts with SMURF1ProteinHetionet hetionet:interacts:10121-57154Inferred only
SPTBN1 interacts with ACTR1AProteinHetionet hetionet:interacts:10121-6711Inferred only
SPTBN2 interacts with ACTR1AProteinHetionet hetionet:interacts:10121-6712Inferred only
SUMO1 interacts with ACTR1AProteinHetionet hetionet:interacts:10121-7341Inferred only

Show the remaining 40

UBC interacts with ACTR1AProteinHetionet hetionet:interacts:10121-7316Inferred only
ACTR1A participates in 16p13 11 copy number variation syndrome PathwayWikiPathways WP5502Inferred only
ACTR1A participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
ACTR1A participates in Affinity selection of immunoglobulinsPathwayReactome R-HSA-9938027Inferred only
ACTR1A participates in Anchoring of the basal body to the plasma membranePathwayReactome R-HSA-5620912Inferred only
ACTR1A participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
ACTR1A participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
ACTR1A participates in AURKA Activation by TPX2PathwayReactome R-HSA-8854518Inferred only
ACTR1A participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
ACTR1A participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
ACTR1A participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
ACTR1A participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
ACTR1A participates in Centrosome maturationPathwayReactome R-HSA-380287Inferred only
ACTR1A participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
ACTR1A participates in COPI-independent Golgi-to-ER retrograde trafficPathwayReactome R-HSA-6811436Inferred only
ACTR1A participates in COPI-mediated anterograde transportPathwayReactome R-HSA-6807878Inferred only
ACTR1A participates in ER to Golgi Anterograde TransportPathwayReactome R-HSA-199977Inferred only
ACTR1A participates in G2/M TransitionPathwayReactome R-HSA-69275Inferred only
ACTR1A participates in Golgi-to-ER retrograde transportPathwayReactome R-HSA-8856688Inferred only
ACTR1A participates in HDAC6 interactions in the central nervous systemPathwayWikiPathways WP5426Inferred only
ACTR1A participates in HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligandPathwayReactome R-HSA-3371497Inferred only
ACTR1A participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
ACTR1A participates in Immunoglobulin maturationPathwayReactome R-HSA-9938026Inferred only
ACTR1A participates in Intra-Golgi and retrograde Golgi-to-ER trafficPathwayReactome R-HSA-6811442Inferred only
ACTR1A participates in Loss of Nlp from mitotic centrosomesPathwayReactome R-HSA-380259Inferred only
ACTR1A participates in Loss of proteins required for interphase microtubule organization from the centrosomePathwayReactome R-HSA-380284Inferred only
ACTR1A participates in M PhasePathwayReactome R-HSA-68886Inferred only
ACTR1A participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
ACTR1A participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ACTR1A participates in MHC class II antigen presentationPathwayReactome R-HSA-2132295Inferred only
ACTR1A participates in Mitotic G2-G2/M phasesPathwayReactome R-HSA-453274Inferred only
ACTR1A participates in Mitotic PrometaphasePathwayReactome R-HSA-68877Inferred only
ACTR1A participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
ACTR1A participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ACTR1A participates in Processing of antigen in germinal center B cellsPathwayReactome R-HSA-9979719Inferred only
ACTR1A participates in Recruitment of mitotic centrosome proteins and complexesPathwayReactome R-HSA-380270Inferred only
ACTR1A participates in Recruitment of NuMA to mitotic centrosomesPathwayReactome R-HSA-380320Inferred only
ACTR1A participates in Regulation of PLK1 Activity at G2/M TransitionPathwayReactome R-HSA-2565942Inferred only
ACTR1A participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
ACTR1A participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Other names

5 names

Resolves to: ACTR1A

Also called: Actin-RPVARP1CentractinCentrosome-associated actin homologCTRN1

← Every protein Find it in the graph →