Proteins/UNIPROT:Q96DG6

CMBL

ProteinUNIPROT:Q96DG6

Cysteine hydrolase whose endogenous substrates and physiological function are unknown. Catalyzes the hydrolytic activation of several ester-based prodrugs, by cleaving the dioxolone ring to yield their respective active metabolites, diacetyl and CO2. Can thus convert the prodrugs Olmesartan medoxomil and Azilsartan medoxomil into their active metabolites (Olmesartan and Azilsartan), two angiotensin receptor blockers. Is also able to activate beta-lactam antibiotics Faropenem medoxomil and Lenampicillin..

Function from UniProtKB (Q96DG6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 2 reference databases · Subject: CMBL · Sources: Hetionet, Reactome

Order

CMBL covaries with TMEM238ProteinHetionet hetionet:covaries:134147-388564Inferred only
PCLAF interacts with CMBLProteinHetionet hetionet:interacts:134147-9768Inferred only
SMURF1 interacts with CMBLProteinHetionet hetionet:interacts:134147-57154Inferred only
UBC interacts with CMBLProteinHetionet hetionet:interacts:134147-7316Inferred only
CMBL participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
CMBL participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CMBL participates in Phase I - Functionalization of compoundsPathwayReactome R-HSA-211945Inferred only

Other names

1 name

Resolves to: CMBL

Also called: Carboxymethylenebutenolidase homolog

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