Proteins/UNIPROT:P68133

ACTA1

ProteinUNIPROT:P68133

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Function from UniProtKB (P68133), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

11 rows

alpha-actinopathy has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0100084Inferred only
childhood-onset nemaline myopathy has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0015738Inferred only
congenital fiber-type disproportion myopathy has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0009711Inferred only
congenital myopathy 2a, typical, autosomal dominant has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0008070Inferred only
congenital myopathy 2c, severe infantile, autosomal dominant has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0859523Inferred only
intermediate nemaline myopathy has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0015736Inferred only
progressive scapulohumeroperoneal distal myopathy has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0014800Inferred only
rigid spine syndrome has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0019951Inferred only
severe congenital nemaline myopathy has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0015735Inferred only
typical nemaline myopathy has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0015737Inferred only
zebra body myopathy has a germline basis in ACTA1DiseaseGenCC HGNC:129|MONDO:0019949Inferred only

Statements

160 statements

160 statements · 4 reference databases · Subject: ACTA1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ACTG1 covaries with ACTA1ProteinHetionet hetionet:covaries:58-71Inferred only
ATP6V0C covaries with ACTA1ProteinHetionet hetionet:covaries:527-58Inferred only
CCNK covaries with ACTA1ProteinHetionet hetionet:covaries:58-8812Inferred only
CELF2 covaries with ACTA1ProteinHetionet hetionet:covaries:10659-58Inferred only
ACTA1 covaries with CNIH3ProteinHetionet hetionet:covaries:149111-58Inferred only
COPZ1 covaries with ACTA1ProteinHetionet hetionet:covaries:22818-58Inferred only
ACTA1 covaries with DEDDProteinHetionet hetionet:covaries:58-9191Inferred only
EEF2 covaries with ACTA1ProteinHetionet hetionet:covaries:1938-58Inferred only
EIF3J covaries with ACTA1ProteinHetionet hetionet:covaries:58-8669Inferred only
ACTA1 covaries with FCRLBProteinHetionet hetionet:covaries:127943-58Inferred only
FOXI3 covaries with ACTA1ProteinHetionet hetionet:covaries:344167-58Inferred only
GALNT9 covaries with ACTA1ProteinHetionet hetionet:covaries:50614-58Inferred only

Show the remaining 148

H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 covaries with ACTA1ProteinHetionet hetionet:covaries:58-8351Inferred only
ACTA1 covaries with KLHL20ProteinHetionet hetionet:covaries:27252-58Inferred only
NAPA covaries with ACTA1ProteinHetionet hetionet:covaries:58-8775Inferred only
NCS1 covaries with ACTA1ProteinHetionet hetionet:covaries:23413-58Inferred only
OTP covaries with ACTA1ProteinHetionet hetionet:covaries:23440-58Inferred only
RAB14 covaries with ACTA1ProteinHetionet hetionet:covaries:51552-58Inferred only
RPL18A covaries with ACTA1ProteinHetionet hetionet:covaries:58-6142Inferred only
ACTA1 covaries with RUSC1ProteinHetionet hetionet:covaries:23623-58Inferred only
SNRPD1 covaries with ACTA1ProteinHetionet hetionet:covaries:58-6632Inferred only
SNX3 covaries with ACTA1ProteinHetionet hetionet:covaries:58-8724Inferred only
ACTA1 covaries with SSU72ProteinHetionet hetionet:covaries:29101-58Inferred only
ACTA1 covaries with ZNF697ProteinHetionet hetionet:covaries:58-90874Inferred only
ABL1 interacts with ACTA1ProteinHetionet hetionet:interacts:25-58Inferred only
ACTA1 interacts with ABRAProteinHetionet hetionet:interacts:137735-58Inferred only
ACTA1 interacts with ACTR10ProteinHetionet hetionet:interacts:55860-58Inferred only
ACTA1 interacts with ACTR1BProteinHetionet hetionet:interacts:10120-58Inferred only
ACTA1 interacts with ADSS2ProteinHetionet hetionet:interacts:159-58Inferred only
ACTA1 interacts with AFAP1ProteinHetionet hetionet:interacts:58-60312Inferred only
ACTA1 interacts with AIF1ProteinHetionet hetionet:interacts:199-58Inferred only
ACTA1 interacts with AJUBAProteinHetionet hetionet:interacts:58-84962Inferred only
ACTA1 interacts with ARRB1ProteinHetionet hetionet:interacts:408-58Inferred only
ACTA1 interacts with CCINProteinHetionet hetionet:interacts:58-881Inferred only
ACTA1 interacts with CCT2ProteinHetionet hetionet:interacts:10576-58Inferred only
ACTA1 interacts with CCT4ProteinHetionet hetionet:interacts:10575-58Inferred only
ACTA1 interacts with CCT5ProteinHetionet hetionet:interacts:22948-58Inferred only
ACTA1 interacts with CDH2ProteinHetionet hetionet:interacts:1000-58Inferred only
ACTA1 interacts with CDK2ProteinHetionet hetionet:interacts:1017-58Inferred only
ACTA1 interacts with CFL1ProteinHetionet hetionet:interacts:1072-58Inferred only
ACTA1 interacts with CLIC5ProteinHetionet hetionet:interacts:53405-58Inferred only
ACTA1 interacts with CNN1ProteinHetionet hetionet:interacts:1264-58Inferred only
ACTA1 interacts with CORO2BProteinHetionet hetionet:interacts:10391-58Inferred only
ACTA1 interacts with COTL1ProteinHetionet hetionet:interacts:23406-58Inferred only
ACTA1 interacts with CTNND1ProteinHetionet hetionet:interacts:1500-58Inferred only
ACTA1 interacts with CTTNProteinHetionet hetionet:interacts:2017-58Inferred only
ACTA1 interacts with CUL1ProteinHetionet hetionet:interacts:58-8454Inferred only
ACTA1 interacts with CYFIP1ProteinHetionet hetionet:interacts:23191-58Inferred only
ACTA1 interacts with CYTH1ProteinHetionet hetionet:interacts:58-9267Inferred only
ACTA1 interacts with DHX9ProteinHetionet hetionet:interacts:1660-58Inferred only
ACTA1 interacts with DLG1ProteinHetionet hetionet:interacts:1739-58Inferred only
ACTA1 interacts with DMDProteinHetionet hetionet:interacts:1756-58Inferred only
ACTA1 interacts with DNASE1ProteinHetionet hetionet:interacts:1773-58Inferred only
ACTA1 interacts with DNMBPProteinHetionet hetionet:interacts:23268-58Inferred only
ACTA1 interacts with DTNAProteinHetionet hetionet:interacts:1837-58Inferred only
ACTA1 interacts with EGFRProteinHetionet hetionet:interacts:1956-58Inferred only
ACTA1 interacts with EPB41ProteinHetionet hetionet:interacts:2035-58Inferred only
ACTA1 interacts with EPB41L2ProteinHetionet hetionet:interacts:2037-58Inferred only
ACTA1 interacts with EPS8ProteinHetionet hetionet:interacts:2059-58Inferred only
ACTA1 interacts with ESR1ProteinHetionet hetionet:interacts:2099-58Inferred only
ACTA1 interacts with FGD4ProteinHetionet hetionet:interacts:121512-58Inferred only
ACTA1 interacts with FHOD1ProteinHetionet hetionet:interacts:29109-58Inferred only
ACTA1 interacts with FSCN1ProteinHetionet hetionet:interacts:58-6624Inferred only
ACTA1 interacts with GAS2ProteinHetionet hetionet:interacts:2620-58Inferred only
ACTA1 interacts with GAS7ProteinHetionet hetionet:interacts:58-8522Inferred only
ACTA1 interacts with GCProteinHetionet hetionet:interacts:2638-58Inferred only
ACTA1 interacts with GSNProteinHetionet hetionet:interacts:2934-58Inferred only
ACTA1 interacts with HCLS1ProteinHetionet hetionet:interacts:3059-58Inferred only
ACTA1 interacts with HDAC4ProteinHetionet hetionet:interacts:58-9759Inferred only
ACTA1 interacts with HDAC8ProteinHetionet hetionet:interacts:55869-58Inferred only
ACTA1 interacts with HIP1RProteinHetionet hetionet:interacts:58-9026Inferred only
ACTA1 interacts with HTRA2ProteinHetionet hetionet:interacts:27429-58Inferred only
ACTA1 interacts with IQGAP1ProteinHetionet hetionet:interacts:58-8826Inferred only
ACTA1 interacts with ISG15ProteinHetionet hetionet:interacts:58-9636Inferred only
ACTA1 interacts with ITGA2ProteinHetionet hetionet:interacts:3673-58Inferred only
ACTA1 interacts with ITPKAProteinHetionet hetionet:interacts:3706-58Inferred only
ACTA1 interacts with KIF23ProteinHetionet hetionet:interacts:58-9493Inferred only
ACTA1 interacts with KLHL20ProteinHetionet hetionet:interacts:27252-58Inferred only
ACTA1 interacts with LASP1ProteinHetionet hetionet:interacts:3927-58Inferred only
ACTA1 interacts with MACF1ProteinHetionet hetionet:interacts:23499-58Inferred only
ACTA1 interacts with MAP1AProteinHetionet hetionet:interacts:4130-58Inferred only
ACTA1 interacts with MIB2ProteinHetionet hetionet:interacts:142678-58Inferred only
ACTA1 interacts with MINPP1ProteinHetionet hetionet:interacts:58-9562Inferred only
ACTA1 interacts with MYL1ProteinHetionet hetionet:interacts:4632-58Inferred only
ACTA1 interacts with MYO10ProteinHetionet hetionet:interacts:4651-58Inferred only
ACTA1 interacts with MYO6ProteinHetionet hetionet:interacts:4646-58Inferred only
ACTA1 interacts with MYO7AProteinHetionet hetionet:interacts:4647-58Inferred only
ACTA1 interacts with MYO9BProteinHetionet hetionet:interacts:4650-58Inferred only
ACTA1 interacts with NEXNProteinHetionet hetionet:interacts:58-91624Inferred only
ACTA1 interacts with NR3C2ProteinHetionet hetionet:interacts:4306-58Inferred only
ACTA1 interacts with OCLNProteinHetionet hetionet:interacts:100506658-58Inferred only
ACTA1 interacts with PAK1ProteinHetionet hetionet:interacts:5058-58Inferred only
ACTA1 interacts with PCLAFProteinHetionet hetionet:interacts:58-9768Inferred only
ACTA1 interacts with PCYT1BProteinHetionet hetionet:interacts:58-9468Inferred only
ACTA1 interacts with PFDN1ProteinHetionet hetionet:interacts:5201-58Inferred only
ACTA1 interacts with PHACTR1ProteinHetionet hetionet:interacts:221692-58Inferred only
ACTA1 interacts with PLD1ProteinHetionet hetionet:interacts:5337-58Inferred only
ACTA1 interacts with PPP1R9BProteinHetionet hetionet:interacts:58-84687Inferred only
ACTA1 interacts with PRKCAProteinHetionet hetionet:interacts:5578-58Inferred only
ACTA1 interacts with PRKCEProteinHetionet hetionet:interacts:5581-58Inferred only
ACTA1 interacts with PTPN1ProteinHetionet hetionet:interacts:5770-58Inferred only
ACTA1 interacts with RAC1ProteinHetionet hetionet:interacts:58-5879Inferred only
ACTA1 interacts with RNF167ProteinHetionet hetionet:interacts:26001-58Inferred only
ACTA1 interacts with RPS6KB1ProteinHetionet hetionet:interacts:58-6198Inferred only
ACTA1 interacts with S100A1ProteinHetionet hetionet:interacts:58-6271Inferred only
ACTA1 interacts with S100A4ProteinHetionet hetionet:interacts:58-6275Inferred only
ACTA1 interacts with SMTNProteinHetionet hetionet:interacts:58-6525Inferred only
ACTA1 interacts with SMURF2ProteinHetionet hetionet:interacts:58-64750Inferred only
ACTA1 interacts with SNCAProteinHetionet hetionet:interacts:58-6622Inferred only
ACTA1 interacts with SORBS1ProteinHetionet hetionet:interacts:10580-58Inferred only
ACTA1 interacts with SPRR1AProteinHetionet hetionet:interacts:58-6698Inferred only
ACTA1 interacts with SPTA1ProteinHetionet hetionet:interacts:58-6708Inferred only
ACTA1 interacts with SPTBN2ProteinHetionet hetionet:interacts:58-6712Inferred only
ACTA1 interacts with SRCProteinHetionet hetionet:interacts:58-6714Inferred only
ACTA1 interacts with TAGLNProteinHetionet hetionet:interacts:58-6876Inferred only
ACTA1 interacts with TJP1ProteinHetionet hetionet:interacts:58-7082Inferred only
ACTA1 interacts with TMSB4XProteinHetionet hetionet:interacts:58-7114Inferred only
ACTA1 interacts with TMSB4YProteinHetionet hetionet:interacts:58-9087Inferred only
ACTA1 interacts with TNNI1ProteinHetionet hetionet:interacts:58-7135Inferred only
ACTA1 interacts with TNNI3ProteinHetionet hetionet:interacts:58-7137Inferred only
ACTA1 interacts with TNNI3KProteinHetionet hetionet:interacts:51086-58Inferred only
ACTA1 interacts with TP53ProteinHetionet hetionet:interacts:58-7157Inferred only
ACTA1 interacts with TPM2ProteinHetionet hetionet:interacts:58-7169Inferred only
ACTA1 interacts with TPM3ProteinHetionet hetionet:interacts:58-7170Inferred only
ACTA1 interacts with TRIM63ProteinHetionet hetionet:interacts:58-84676Inferred only
ACTA1 interacts with TTNProteinHetionet hetionet:interacts:58-7273Inferred only
ACTA1 interacts with UBCProteinHetionet hetionet:interacts:58-7316Inferred only
ACTA1 interacts with UBL4AProteinHetionet hetionet:interacts:58-8266Inferred only
ACTA1 interacts with USP25ProteinHetionet hetionet:interacts:29761-58Inferred only
ACTA1 interacts with USP6NLProteinHetionet hetionet:interacts:58-9712Inferred only
ACTA1 interacts with UTRNProteinHetionet hetionet:interacts:58-7402Inferred only
ACTA1 interacts with VAV1ProteinHetionet hetionet:interacts:58-7409Inferred only
ACTA1 interacts with VCLProteinHetionet hetionet:interacts:58-7414Inferred only
ACTA1 interacts with VIL1ProteinHetionet hetionet:interacts:58-7429Inferred only
ACTA1 interacts with XIRP1ProteinHetionet hetionet:interacts:165904-58Inferred only
ACTA1 interacts with ZNF16ProteinHetionet hetionet:interacts:58-7564Inferred only
ACTA1 participates in Activation of STAT3 by cadherin engagementPathwayReactome R-HSA-9958825Inferred only
ACTA1 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
ACTA1 participates in Burn wound healingPathwayWikiPathways WP5055Inferred only
ACTA1 participates in Caffeine in myocytesPathwayWikiPathways WP5603Inferred only
ACTA1 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
ACTA1 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
ACTA1 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
ACTA1 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ACTA1 participates in Fas ligand pathway and stress induction of heat shock proteinsPathwayWikiPathways WP314Inferred only
ACTA1 participates in Formation of the dystrophin-glycoprotein complex (DGC)PathwayReactome R-HSA-9913351Inferred only
ACTA1 participates in HSPB3 in Charcot Marie Tooth diseasePathwayWikiPathways WP5524Inferred only
ACTA1 participates in Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanismsPathwayWikiPathways WP4534Inferred only
ACTA1 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
ACTA1 participates in Myometrial relaxation and contraction pathwaysPathwayWikiPathways WP289Inferred only
ACTA1 participates in Non-integrin membrane-ECM interactionsPathwayReactome R-HSA-3000171Inferred only
ACTA1 participates in Physico chemical features and toxicity associated pathwaysPathwayWikiPathways WP3680Inferred only
ACTA1 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
ACTA1 participates in Regulation of CDH1 Expression and FunctionPathwayReactome R-HSA-9764265Inferred only
ACTA1 participates in Regulation of CDH1 FunctionPathwayReactome R-HSA-9764561Inferred only
ACTA1 participates in Regulation of Expression and Function of Type I Classical CadherinsPathwayReactome R-HSA-9764274Inferred only
ACTA1 participates in Regulation of Homotypic Cell-Cell AdhesionPathwayReactome R-HSA-9759476Inferred only
ACTA1 participates in Striated Muscle ContractionPathwayReactome R-HSA-390522Inferred only
ACTA1 participates in Striated muscle contraction pathwayPathwayWikiPathways WP383Inferred only
ACTA1 regulates positive regulation of gene expressionBiological processgene ontology P68133|GO:0010628Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

3 names

Resolves to: ACTA1

Also called: [Cleaved into: Actin, alpha skeletal muscle, intermediate form]ACTAAlpha-actin-1

← Every protein Find it in the graph →