Proteins/UNIPROT:P15170

GSPT1

ProteinUNIPROT:P15170

GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA. GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes..

Function from UniProtKB (P15170), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

43 statements

43 statements · 3 reference databases · Subject: GSPT1 · Sources: gene ontology, Hetionet, Reactome

Order

GSPT1 covaries with BTRCProteinHetionet hetionet:covaries:2935-8945Inferred only
DCXR covaries with GSPT1ProteinHetionet hetionet:covaries:2935-51181Inferred only
FOXC2 covaries with GSPT1ProteinHetionet hetionet:covaries:2303-2935Inferred only
MROH5 covaries with GSPT1ProteinHetionet hetionet:covaries:2935-389690Inferred only
NWD1 covaries with GSPT1ProteinHetionet hetionet:covaries:284434-2935Inferred only
GSPT1 interacts with ATXN1ProteinHetionet hetionet:interacts:2935-6310Inferred only
BIRC2 interacts with GSPT1ProteinHetionet hetionet:interacts:2935-329Inferred only
BIRC3 interacts with GSPT1ProteinHetionet hetionet:interacts:2935-330Inferred only
CDKN2A interacts with GSPT1ProteinHetionet hetionet:interacts:1029-2935Inferred only
ETF1 interacts with GSPT1ProteinHetionet hetionet:interacts:2107-2935Inferred only
GSPT1 interacts with GSPT2ProteinHetionet hetionet:interacts:23708-2935Inferred only
GSPT1 interacts with HINFPProteinHetionet hetionet:interacts:25988-2935Inferred only

Show the remaining 31

GSPT1 interacts with IKBKEProteinHetionet hetionet:interacts:2935-9641Inferred only
GSPT1 interacts with MAP3K5ProteinHetionet hetionet:interacts:2935-4217Inferred only
GSPT1 interacts with PABPC1ProteinHetionet hetionet:interacts:26986-2935Inferred only
GSPT1 interacts with PCLAFProteinHetionet hetionet:interacts:2935-9768Inferred only
GSPT1 interacts with PIK3R1ProteinHetionet hetionet:interacts:2935-5295Inferred only
GSPT1 interacts with PRKAB1ProteinHetionet hetionet:interacts:2935-5564Inferred only
GSPT1 interacts with RNASELProteinHetionet hetionet:interacts:2935-6041Inferred only
GSPT1 interacts with SUMO2ProteinHetionet hetionet:interacts:2935-6613Inferred only
GSPT1 interacts with TRAF6ProteinHetionet hetionet:interacts:2935-7189Inferred only
GSPT1 interacts with UBCProteinHetionet hetionet:interacts:2935-7316Inferred only
GSPT1 interacts with VHLProteinHetionet hetionet:interacts:2935-7428Inferred only
XIAP interacts with GSPT1ProteinHetionet hetionet:interacts:2935-331Inferred only
GSPT1 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
GSPT1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
GSPT1 participates in Eukaryotic Translation TerminationPathwayReactome R-HSA-72764Inferred only
GSPT1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
GSPT1 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
GSPT1 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
GSPT1 participates in Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)PathwayReactome R-HSA-975957Inferred only
GSPT1 participates in Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)PathwayReactome R-HSA-975956Inferred only
GSPT1 participates in Nonsense-Mediated Decay (NMD)PathwayReactome R-HSA-927802Inferred only
GSPT1 participates in Regulation of expression of SLITs and ROBOsPathwayReactome R-HSA-9010553Inferred only
GSPT1 participates in Signaling by ROBO receptorsPathwayReactome R-HSA-376176Inferred only
GSPT1 participates in TranslationPathwayReactome R-HSA-72766Inferred only
GSPT1 regulates regulation of translational terminationBiological processgene ontology P15170|GO:0006449Inferred only
CTSK increases the expression of GSPT1ProteinHetionet hetionet:regulates:1513-2935Inferred only
EIF2AK3 decreases the expression of GSPT1ProteinHetionet hetionet:regulates:9451-2935Inferred only
PABPC1 increases the expression of GSPT1ProteinHetionet hetionet:regulates:26986-2935Inferred only
RFXANK increases the expression of GSPT1ProteinHetionet hetionet:regulates:8625-2935Inferred only
RPN1 decreases the expression of GSPT1ProteinHetionet hetionet:regulates:6184-2935Inferred only
USP7 decreases the expression of GSPT1ProteinHetionet hetionet:regulates:7874-2935Inferred only

Reactions

1 reaction

GTP+waterGDP+hydrogenphosphate+hydron
Catalysed by IRGM or RAB19 or TUBAL3 or GTPBP1 or RAB27B or RHOD or DNM1L or MRAS or RAB29 or OPA1 or EIF5B or ENTPD3 and 183 more alternatives
Reaction page

Other names

3 names

Resolves to: GSPT1

Also called: ERF3AEukaryotic peptide chain release factor subunit 3aG1 to S phase transition protein 1 homolog

← Every protein Find it in the graph →