DSG1

A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Promotes differentiation of keratinocytes via interaction with ERBIN. Reduces activation of RAS/ERK signaling pathways in keratinocytes via promoting ERBIN localization to the cell membrane and its interaction with SHOC2, this competitively reduces the formation of RAS-SHOC2 ERK-activating complexes. Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex. As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane. Critical for epidermal integrity and barrier function of the skin (By similarity). May mediate the inflammatory response in the epidermis (By similarity). Required for esophageal epithelial barrier integrity and correct intercellular spacing in differentiated esophageal epithelium. Required for recovery of epidermal architecture and correct expression of differentiation markers following UVB exposure. May also be required for OCLN involvement in tight junctions (By similarity)..

Function from UniProtKB (Q02413), read 2026-09-23. CC BY 4.0.