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Proteins/UNIPROT:P53675

CLTCL1

Protein·UNIPROT:P53675

Open in the graph

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity)..

Function from UniProtKB (P53675), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

congenital insensitivity to pain with severe intellectual disability has a germline basis in CLTCL1DiseaseGenCC HGNC:2093|MONDO:0018682Inferred only

Statements

34 statements

34 statements · 4 reference databases · Subject: CLTCL1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CLTCL1 covaries with ACTR10ProteinHetionet hetionet:covaries:55860-8218Inferred only
CLTCL1 interacts with CAND1ProteinHetionet hetionet:interacts:55832-8218Inferred only
CFTR interacts with CLTCL1ProteinHetionet hetionet:interacts:1080-8218Inferred only
CLTCL1 interacts with COPS5ProteinHetionet hetionet:interacts:10987-8218Inferred only
CLTCL1 interacts with COPS6ProteinHetionet hetionet:interacts:10980-8218Inferred only
CLTCL1 interacts with CUL1ProteinHetionet hetionet:interacts:8218-8454Inferred only
CLTCL1 interacts with CUL3ProteinHetionet hetionet:interacts:8218-8452Inferred only
EGFR interacts with CLTCL1ProteinHetionet hetionet:interacts:1956-8218Inferred only
ESR1 interacts with CLTCL1ProteinHetionet hetionet:interacts:2099-8218Inferred only
HIP1 interacts with CLTCL1ProteinHetionet hetionet:interacts:3092-8218Inferred only
NEDD8 interacts with CLTCL1ProteinHetionet hetionet:interacts:4738-8218Inferred only
CLTCL1 interacts with PCLAFProteinHetionet hetionet:interacts:8218-9768Inferred only

Show the remaining 22

CLTCL1 interacts with PICALMProteinHetionet hetionet:interacts:8218-8301Inferred only
CLTCL1 interacts with SNX5ProteinHetionet hetionet:interacts:27131-8218Inferred only
UBC interacts with CLTCL1ProteinHetionet hetionet:interacts:7316-8218Inferred only
CLTCL1 participates in 22q11 2 copy number variation syndromePathwayWikiPathways WP4657Inferred only
CLTCL1 participates in 4p16 3 copy number variationPathwayWikiPathways WP5365Inferred only
CLTCL1 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
CLTCL1 participates in Cargo recognition for clathrin-mediated endocytosisPathwayReactome R-HSA-8856825Inferred only
CLTCL1 participates in Clathrin-mediated endocytosisPathwayReactome R-HSA-8856828Inferred only
CLTCL1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
CLTCL1 participates in Ebola virus infection in hostPathwayWikiPathways WP4217Inferred only
CLTCL1 participates in EPH-ephrin mediated repulsion of cellsPathwayReactome R-HSA-3928665Inferred only
CLTCL1 participates in EPH-Ephrin signalingPathwayReactome R-HSA-2682334Inferred only
CLTCL1 participates in Formation of annular gap junctionsPathwayReactome R-HSA-196025Inferred only
CLTCL1 participates in Fragile X syndromePathwayWikiPathways WP4549Inferred only
CLTCL1 participates in Gap junction degradationPathwayReactome R-HSA-190873Inferred only
CLTCL1 participates in Gap junction traffickingPathwayReactome R-HSA-190828Inferred only
CLTCL1 participates in Gap junction trafficking and regulationPathwayReactome R-HSA-157858Inferred only
CLTCL1 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
CLTCL1 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
CLTCL1 participates in Synaptic vesicle pathwayPathwayWikiPathways WP2267Inferred only
CLTCL1 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
CLTCL1 regulates positive regulation of D-glucose import across plasma membraneBiological processgene ontology P53675|GO:0046326Inferred only

Other names

5 names

Resolves to: CLTCL1

Also called: Clathrin heavy chain on chromosome 22CLH-22CLH22CLTCLCLTD

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