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Proteins/UNIPROT:Q14766
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta..
Function from UniProtKB (Q14766), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
29 statements
29 statements · 3 reference databases · Subject: LTBP1 · Sources: Hetionet, Reactome, WikiPathways
3 names
Resolves to: LTBP1