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Proteins/UNIPROT:Q9H000
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity)..
Function from UniProtKB (Q9H000), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
25 statements
25 statements · 2 reference databases · Subject: MKRN2 · Sources: gene ontology, Hetionet
1 reaction
3 names
Resolves to: MKRN2
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol
Human-GEM MAR09491CC BY 4.0Reference data