Pathway

Defective HPRT1 disrupts guanine and hypoxanthine salvage

Normally in humans, guanine and hypoxanthine can be salvaged by conversion to GMP and IMP, catalyzed by HPRT1 (hypoxanthine guanine phosphoribosyltransferase). In the absence of HPRT1 activity, however, accumulated guanine and hypoxanthine are catabolized by XDH (xanthine dehydrogenase / oxidase) to urate.

Summary from Reactome (R-HSA-9734281), read 2026-09-23.

REACT:R-HSA-9734281Reactome

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What the reference databases state

Statements

1 statement

1 statement · 1 reference database · Subject: Defective HPRT1 disrupts guanine and hypoxanthine salvage · Sources: Reactome

Order

HPRT1 participates in Defective HPRT1 disrupts guanine and hypoxanthine salvageProteinReactome R-HSA-9734281Inferred only