Proteins/UNIPROT:P19957

PI3

ProteinUNIPROT:P19957

Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1)..

Function from UniProtKB (P19957), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 3 reference databases · Subject: PI3 · Sources: Hetionet, Reactome, WikiPathways

Order

PI3 covaries with KLF11ProteinHetionet hetionet:covaries:5266-8462Inferred only
MAP3K15 covaries with PI3ProteinHetionet hetionet:covaries:389840-5266Inferred only
TMEM132D covaries with PI3ProteinHetionet hetionet:covaries:121256-5266Inferred only
PI3 covaries with USP36ProteinHetionet hetionet:covaries:5266-57602Inferred only
CELA1 interacts with PI3ProteinHetionet hetionet:interacts:1990-5266Inferred only
CSTA interacts with PI3ProteinHetionet hetionet:interacts:1475-5266Inferred only
KRT1 interacts with PI3ProteinHetionet hetionet:interacts:3848-5266Inferred only
LORICRIN interacts with PI3ProteinHetionet hetionet:interacts:4014-5266Inferred only
PI3 participates in Antimicrobial peptidesPathwayReactome R-HSA-6803157Inferred only
PI3 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
PI3 participates in Effect of omega 3 PUFA on Huntington 39 s disease pathwaysPathwayWikiPathways WP5470Inferred only
PI3 participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only

Show the remaining 15

PI3 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
PI3 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
PI3 participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only
ABCF1 increases the expression of PI3ProteinHetionet hetionet:regulates:23-5266Inferred only
HK1 increases the expression of PI3ProteinHetionet hetionet:regulates:3098-5266Inferred only
HPRT1 increases the expression of PI3ProteinHetionet hetionet:regulates:3251-5266Inferred only
IL13RA2 increases the expression of PI3ProteinHetionet hetionet:regulates:3598-5266Inferred only
MTF2 increases the expression of PI3ProteinHetionet hetionet:regulates:22823-5266Inferred only
NENF increases the expression of PI3ProteinHetionet hetionet:regulates:29937-5266Inferred only
NPRL2 increases the expression of PI3ProteinHetionet hetionet:regulates:10641-5266Inferred only
NR2F6 increases the expression of PI3ProteinHetionet hetionet:regulates:2063-5266Inferred only
PCBD1 increases the expression of PI3ProteinHetionet hetionet:regulates:5092-5266Inferred only
PMM2 increases the expression of PI3ProteinHetionet hetionet:regulates:5373-5266Inferred only
PRKAR2B increases the expression of PI3ProteinHetionet hetionet:regulates:5577-5266Inferred only
RARA increases the expression of PI3ProteinHetionet hetionet:regulates:5914-5266Inferred only

Other names

10 names

Resolves to: PI3

Also called: Elastase-specific inhibitorESIPeptidase inhibitor 3PI-3Protease inhibitor WAP3SKALPSkin-derived antileukoproteinaseWAP four-disulfide core domain protein 14WAP3WFDC14

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