Proteins/UNIPROT:P18433

PTPRA

ProteinUNIPROT:P18433

Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity)..

Function from UniProtKB (P18433), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 4 reference databases · Subject: PTPRA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

PTPRA interacts with BCAR1ProteinHetionet hetionet:interacts:5786-9564Inferred only
CALM1 interacts with PTPRAProteinHetionet hetionet:interacts:5786-801Inferred only
CALM1 interacts with PTPRAProteinHetionet hetionet:interacts:5786-808Inferred only
CALM1 interacts with PTPRAProteinHetionet hetionet:interacts:5786-805Inferred only
GRB2 interacts with PTPRAProteinHetionet hetionet:interacts:2885-5786Inferred only
KCNA2 interacts with PTPRAProteinHetionet hetionet:interacts:3737-5786Inferred only
PTPRA interacts with PTPRFProteinHetionet hetionet:interacts:5786-5792Inferred only
PTPRA interacts with PTPRMProteinHetionet hetionet:interacts:5786-5797Inferred only
PTPRA interacts with PTPRSProteinHetionet hetionet:interacts:5786-5802Inferred only
PTPRA interacts with SRCProteinHetionet hetionet:interacts:5786-6714Inferred only
PTPRA participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
PTPRA participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only

Show the remaining 15

PTPRA participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
PTPRA participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
PTPRA participates in Microtubule cytoskeleton regulationPathwayWikiPathways WP2038Inferred only
PTPRA participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
PTPRA participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
PTPRA participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
PTPRA participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PTPRA participates in Spinal cord injuryPathwayWikiPathways WP2431Inferred only
PTPRA regulates regulation of focal adhesion assemblyBiological processgene ontology P18433|GO:0051893Inferred only
DFFB decreases the expression of PTPRAProteinHetionet hetionet:regulates:1677-5786Inferred only
FASTKD5 decreases the expression of PTPRAProteinHetionet hetionet:regulates:60493-5786Inferred only
GPR26 decreases the expression of PTPRAProteinHetionet hetionet:regulates:2849-5786Inferred only
LRSAM1 decreases the expression of PTPRAProteinHetionet hetionet:regulates:90678-5786Inferred only
MLEC decreases the expression of PTPRAProteinHetionet hetionet:regulates:9761-5786Inferred only
NR3C1 decreases the expression of PTPRAProteinHetionet hetionet:regulates:2908-5786Inferred only

Reactions

1 reaction

O-phospho-L-tyrosyl-[protein]+waterL-tyrosyl-[protein]+hydrogenphosphate
Catalysed by PGP or EYA2 or PTPRT or CDC14B or PTP4A3 or DUSP14 or EPM2A or EYA4 or PTPRC or PTPRF or ACP3 or PTPN2 and 71 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

4 names

Resolves to: PTPRA

Also called: Protein-tyrosine phosphatase alphaPTPAPTPRL2R-PTP-alpha

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