Proteins/UNIPROT:P57071

PRDM15

ProteinUNIPROT:P57071

Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Also plays a role in induced pluripotent stem cells (iPSCs) reprogramming..

Function from UniProtKB (P57071), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

multiple congenital anomalies/dysmorphic syndrome has a germline basis in PRDM15DiseaseGenCC HGNC:13999|MONDO:0019042Inferred only

Statements

16 statements

16 statements · 2 reference databases · Subject: PRDM15 · Sources: gene ontology, Hetionet

Order

PRDM15 covaries with AACSProteinHetionet hetionet:covaries:63977-65985Inferred only
AADAT covaries with PRDM15ProteinHetionet hetionet:covaries:51166-63977Inferred only
C21orf58 covaries with PRDM15ProteinHetionet hetionet:covaries:54058-63977Inferred only
PRDM15 covaries with DFFBProteinHetionet hetionet:covaries:1677-63977Inferred only
PRDM15 covaries with dikProteinHetionet hetionet:covaries:54101-63977Inferred only
DYNC2I1 covaries with PRDM15ProteinHetionet hetionet:covaries:55112-63977Inferred only
HSD17B11 covaries with PRDM15ProteinHetionet hetionet:covaries:51170-63977Inferred only
PITRM1 covaries with PRDM15ProteinHetionet hetionet:covaries:10531-63977Inferred only
PTPRN2 covaries with PRDM15ProteinHetionet hetionet:covaries:5799-63977Inferred only
SLC6A18 covaries with PRDM15ProteinHetionet hetionet:covaries:348932-63977Inferred only
PRDM15 covaries with TBCDProteinHetionet hetionet:covaries:63977-6904Inferred only
PRDM15 regulates negative regulation of MAPK cascadeBiological processgene ontology P57071|GO:0043409Inferred only

Show the remaining 4

PRDM15 regulates positive regulation of canonical Wnt signaling pathwayBiological processgene ontology P57071|GO:0090263Inferred only
PRDM15 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P57071|GO:0045944Inferred only
PRDM15 regulates regulation of stem cell divisionBiological processgene ontology P57071|GO:2000035Inferred only
PRDM15 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P57071|GO:0006357Inferred only

Other names

4 names

Resolves to: PRDM15

Also called: C21orf83PR domain-containing protein 15Zinc finger protein 298ZNF298

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