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Proteins/UNIPROT:P37023
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well..
Function from UniProtKB (P37023), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
51 statements
51 statements · 5 reference databases · Subject: ACVRL1 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
2 reactions
9 names
Resolves to: ACVRL1
Rhea RHEA:18673CC BY 4.0Reference data
L-threonyl-[receptor-protein]+ATP(4-)O-phospho-L-threonyl-[receptor-protein]+ADP(3-)+hydron
Catalysed by BMPR1B or ACVR2A or BMPR1A or ACVR1B or TGFBR1 or ACVRL1 or TGFBR2 or ACVR1 or ACVR2B or BMPR2 or AMHR2 or ACVR1C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:44880CC BY 4.0Reference data