Pathway
Transcriptional activation of mitochondrial biogenesis
Phosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate the transcription of nuclear-encoded, mitochondrially targeted proteins such as TFB2M, TFB1M, and TFAM. PGC-1beta and PPRC appear to act similarly to PGC-1alpha but have not been as well studied. Transcription of PPARGC1A itself is upregulated by CREB1 (in response to calcium), MEF2C/D, ATF2, and PPARGC1A. Transcription of PPARGC1A is repressed by NR1D1 (REV-ERBA).
REACT:R-HSA-2151201Reactome
What the reference databases state
Statements
52 statements
52 statements · 1 reference database · Subject: Transcriptional activation of mitochondrial biogenesis · Sources: Reactome
- ACSS2 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- ALAS1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- ATF2 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- ATP5F1B participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- CALM1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- CAMK4 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- CARM1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- CHD9 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- CREBBP participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- CRTC1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- CRTC2 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- CRTC3 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
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- CYCS participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- ESRRA participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- GABPA participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- GLUD1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- GLUD2 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- HCFC1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- HDAC3 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- HELZ2 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- IDH2 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- MED1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- MEF2C participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- MEF2D participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- MTERF1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- NCOA1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- NCOA2 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- NCOA6 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- NCOR1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- NR1D1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- NRF1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- PERM1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- POLG2 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- POLRMT participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- PPARA participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- PPARGC1A participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- PPARGC1B participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- PPRC1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- RXRA participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- SIRT3 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- SIRT4 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- SIRT5 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- SMARCD3 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- SOD2 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- SSBP1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- TBL1X participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- TBL1XR1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- TFAM participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- TFB1M participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- TFB2M participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- TGS1 participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only
- TWNK participates in Transcriptional activation of mitochondrial biogenesisProteinReactome R-HSA-2151201Inferred only