Proteins/UNIPROT:Q7Z5J4

RAI1

ProteinUNIPROT:Q7Z5J4

Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation..

Function from UniProtKB (Q7Z5J4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

Potocki-Lupski syndrome has a germline basis in RAI1DiseaseGenCC HGNC:9834|MONDO:0012574Inferred only
Smith-Magenis syndrome has a germline basis in RAI1DiseaseGenCC HGNC:9834|MONDO:0008434Inferred only

Statements

28 statements

28 statements · 4 reference databases · Subject: RAI1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

RAI1 covaries with FAM234BProteinHetionet hetionet:covaries:10743-57613Inferred only
CASP2 interacts with RAI1ProteinHetionet hetionet:interacts:10743-835Inferred only
CDKN1A interacts with RAI1ProteinHetionet hetionet:interacts:1026-10743Inferred only
DDIT3 interacts with RAI1ProteinHetionet hetionet:interacts:10743-1649Inferred only
GADD45A interacts with RAI1ProteinHetionet hetionet:interacts:10743-1647Inferred only
GATA1 interacts with RAI1ProteinHetionet hetionet:interacts:10743-2623Inferred only
GLI1 interacts with RAI1ProteinHetionet hetionet:interacts:10743-2735Inferred only
GSK3B interacts with RAI1ProteinHetionet hetionet:interacts:10743-2932Inferred only
LZTR1 interacts with RAI1ProteinHetionet hetionet:interacts:10743-8216Inferred only
RAI1 interacts with MAML3ProteinHetionet hetionet:interacts:10743-55534Inferred only
RAI1 interacts with MAPK8IP2ProteinHetionet hetionet:interacts:10743-23542Inferred only
PIN1 interacts with RAI1ProteinHetionet hetionet:interacts:10743-5300Inferred only

Show the remaining 16

RPS6KA5 interacts with RAI1ProteinHetionet hetionet:interacts:10743-9252Inferred only
RAI1 interacts with SIRT7ProteinHetionet hetionet:interacts:10743-51547Inferred only
SUMO2 interacts with RAI1ProteinHetionet hetionet:interacts:10743-6613Inferred only
RAI1 interacts with TESCProteinHetionet hetionet:interacts:10743-54997Inferred only
TTR interacts with RAI1ProteinHetionet hetionet:interacts:10743-7276Inferred only
UBC interacts with RAI1ProteinHetionet hetionet:interacts:10743-7316Inferred only
RAI1 interacts with ZNF496ProteinHetionet hetionet:interacts:10743-84838Inferred only
RAI1 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
RAI1 participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
RAI1 participates in Circadian clockPathwayReactome R-HSA-9909396Inferred only
RAI1 participates in Circadian rhythm genesPathwayWikiPathways WP3594Inferred only
RAI1 participates in Expression of BMAL (ARNTL), CLOCK, and NPAS2PathwayReactome R-HSA-9931509Inferred only
RAI1 participates in Heme signalingPathwayReactome R-HSA-9707616Inferred only
RAI1 participates in Smith Magenis and Potocki Lupski syndrome copy number variationPathwayWikiPathways WP5381Inferred only
RAI1 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology Q7Z5J4|GO:0045893Inferred only
RAI1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q7Z5J4|GO:0006357Inferred only

Other names

2 names

Resolves to: RAI1

Also called: KIAA1820Retinoic acid-induced protein 1

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