Pathway
Response to elevated platelet cytosolic Ca2+
Activation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium and activation of Protein Kinase C (PKC). Phospholipase C cleaves the phosphodiester bond in PIP2 to form 1,2 Diacylglycerol (DAG) and 1,4,5-inositol trisphosphate (IP3). IP3 opens Ca2+ channels in the platelet dense tubular system, raising intracellular Ca2+ levels. DAG is a second messenger that regulates a family of Ser/Thr kinases consisting of PKC isozymes. DAG achieves activation of PKC isozymes by increasing their affinity for phospholipid. Most PKC enzymes are also calcium-dependent, so their activation is in synergy with the rise in intracellular Ca2+. Platelets contain several PKC isoforms that can be activated by DAG and/or Ca2+.
REACT:R-HSA-76005Reactome
What the reference databases state
Statements
130 statements
130 statements · 1 reference database · Subject: Response to elevated platelet cytosolic Ca2+ · Sources: Reactome
- A1BG participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- A2M participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ABCC4 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ACTN1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ACTN2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ACTN4 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- AHSG participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ALB participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ALDOA participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ANXA5 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- APLP2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- APOA1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
Show the remaining 118
- APOH participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- APOOL participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- APP participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- BRPF3 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CALM1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CALU participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CAP1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CD109 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CD36 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CD63 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CD9 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CDC37L1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CFD participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CFL1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CHID1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CLEC3B participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CLU participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CTSW participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CYB5R1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- CYRIB participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ECM1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- EGF participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ENDOD1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- F13A1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- F5 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- F8 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- FAM3C participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- FERMT3 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- FGA participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- FGB participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- FGG participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- FLNA participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- FN1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- GAS6 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- GTPBP2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- HABP4 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- HGF participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- HRG participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- HSPA5 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- IGF1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- IGF2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ISLR participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ITGA2B participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ITGB3 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ITIH3 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ITIH4 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- KNG1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- LAMP2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- LEFTY2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- LGALS3BP participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- LHFPL2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- LY6G6F participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- MAGED2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- MANF participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- MMRN1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- NHLRC2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- OLA1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ORM1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- ORM2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PCDH7 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PCYOX1L participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PDGFB participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PECAM1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PF4 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PFN1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PHACTR2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PLEK participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PLG participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PPBP participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PPIA participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PRKCA participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PRKCB participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PRKCG participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PROS1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- PSAP participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- QSOX1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- RAB27B participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SCCPDH participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SCG3 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SELENOP participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SELP participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SERPINA1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SERPINA3 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SERPINA4 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SERPINE1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SERPINF2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SERPING1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SOD1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SPARC participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SPP2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SRGN participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- STX4 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- STXBP2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- STXBP3 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- SYTL4 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TAGLN2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TEX264 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TF participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TGFB1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TGFB2 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TGFB3 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- THBS1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TIMP1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TIMP3 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TLN1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TMSB4X participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TMX3 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TOR4A participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TTN participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- TUBA4A participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- VCL participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- VEGFA participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- VEGFB participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- VEGFC participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- VEGFD participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- VTI1B participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- VWF participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only
- WDR1 participates in Response to elevated platelet cytosolic Ca2+ProteinReactome R-HSA-76005Inferred only