7-oxolithocholate

Three steps

• prostaglandin H2Reach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosol

• leukotriene A4Reach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, GLO1 and 1 moreextracellular space, cytosolOne of 2 routes

• S-formylglutathioneReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, ADH1C and 5 moreextracellular space, cytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• glutathioneReach from here →
  1. chenodeoxycholate + NADP(+) = 7-oxolithocholate + NADPH + H(+)
  2. chenodeoxycholate + reduced [NADPH--hemoprotein reductase] + O2 = cholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
  3. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by HSD11B1, CYP8B1, ABCC4inner side of the membrane, outer side of the membrane

• leukotriene C4Reach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. leukotriene C4 synthase (GSH)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, LTC4Sextracellular space, cytosolOne of 6 routes

• glutathione disulfideReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosolOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• histamineReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-thyroxineReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, SQORextracellular space, cytosol, mitochondrial matrix

• dopamineReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• estrone 3-sulfateReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-cysteinylglycineReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, GGTLC3 and 5 moreextracellular space, cytosolOne of 4 routes

• (R)-noradrenalineReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin G2Reach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• thromboxane B2Reach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• taurochenodeoxycholateReach from here →
  1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by HSD11B1, SLCO1A2, SLCO1B3, SLC7A9extracellular space, cytosolOne of 7 routes