docosanoyl-CoA

Two steps

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by BAAT, ACOT6, CPT1A, CPT1Bcytosol

• an all-trans-retinyl esterReach from here →
  1. acyl-CoA pool formation and breakdown
  2. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by DGAT1, PNPLA4, AWAT2, DGAT2cytosol

• CHEBI:63544Reach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2cytosol

• a triacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by DGAT1, MOGAT2, AWAT2, MOGAT3 and 2 morecytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by LCLAT1, LPCAT1, GPAMcytosol

• hexacosanoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• tetracosanoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• N-eicosanoylsphinganineReach from here →
  1. Fatty Acid Beta Oxidation (C22->C20), Peroxisomal
  2. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 3 moreperoxisome

• (2E)-octadecenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 3 routes

• 3-oxodocosanoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C22->C20), Peroxisomal
  2. very-long-chain 3-oxoacyl-CoA synthase (eicosanoyl-CoA)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 7 moreperoxisome, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• N-eicosanoyl-sphing-4-enineReach from here →
  1. Fatty Acid Beta Oxidation (C22->C20), Peroxisomal
  2. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 2 moreperoxisome

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (2E)-eicosenoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C22->C20), Peroxisomal
  2. acyl-CoA oxidase (eicosanoyl-CoA)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 1 moreperoxisomeOne of 4 routes

• 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphateReach from here →
  1. Fatty Acid Beta Oxidation (C22->C20), Peroxisomal
  2. eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 1 moreperoxisome

• nonadecanoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 3 routes

• a 2,3-diacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• eicosan-1-olReach from here →
  1. Fatty Acid Beta Oxidation (C22->C20), Peroxisomal
  2. eicosanoyl-CoA + 2 NADPH + 2 H(+) = eicosan-1-ol + 2 NADP(+) + CoA

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 2 moreperoxisome

• 1-O-alkyl-3-acylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by MOGAT2, AWAT2cytosol

• docosanedioateReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Fatty Acid Omega Oxidation by Hydroxylases (C22->C22Dc), Endoplasmatic Reticulum

  Catalysed by BAAT, ACOT6, CYP4F2, CYP4F3cytosol, endoplasmic reticulum

• dodecanedioyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Activation of dodecanedioic acid

  Catalysed by BAAT, ACOT6cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Production of Sebacoylcarnitine

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Production of Suberylcarnitine

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by BAAT, ACOT6cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by BAAT, ACOT6, CRAT, CROTcytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by BAAT, ACOT6, ACAA1, HSD17B4 and 2 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. Production of Hexadecanedioylcarnitine

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. Docosanoyl-CoA hydrolase
  2. fatty-acid-CoA ligase

  Catalysed by BAAT, ACOT6, SLC27A2cytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by MOGAT1cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT2, LPCAT1cytosol