N-acetyl-D-glucosamine 6-phosphate

Three steps

• phytanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. phytanate-CoA ligase

  Catalysed by CEMP1, AMDHD2, GNPNAT1cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 6 morecytosolOne of 15 routes

• D-sedoheptulose 7-phosphateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)
  3. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase

  Catalysed by CEMP1, AMDHD2, GNPDA1, GNPDA2 and 1 morecytosolOne of 2 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• 2-methyl-3-oxopropanoateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• sphing-4-enineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by CEMP1, AMDHD2, ASAH1cytosolOne of 3 routes

• spermidineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N(8)-acetylspermidine + H2O = spermidine + acetate
  3. N8-acetylspermidine to spermidine conversion

  Catalysed by CEMP1, AMDHD2, HDAC10cytosolOne of 5 routes

• L-methionineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 5 morecytosol, extracellular spaceOne of 2 routes

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosol

• L-alanineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space, mitochondrial matrixOne of 19 routes

• L-asparagineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, NAGScytosol, mitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosol

• alpha-D-glucose 6-phosphateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
  3. alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate

  Catalysed by CEMP1, AMDHD2, GNPDA1, GNPDA2 and 1 morecytosol

• an acyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ASAH1 and 3 morecytosol, Golgi apparatusOne of 2 routes

• cadaverineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-acetylcadaverine + H2O = cadaverine + acetate
  3. N-acetylcadaverine + H2O = cadaverine + acetate

  Catalysed by CEMP1, AMDHD2, HDAC10cytosol

• (3Z)-dodecenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (3S)-citramalyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• an S-substituted L-cysteineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by CEMP1, AMDHD2, ACY3cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• deoxycholoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 1 morecytosolOne of 4 routes

• D-glyceraldehyde 3-phosphateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
  3. D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate

  Catalysed by CEMP1, AMDHD2, GNPDA1, GNPDA2 and 1 morecytosolOne of 2 routes

• decanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ACSM4 and 5 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by CEMP1, AMDHD2, GNPNAT1, CPT1A and 2 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 11 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• 3-hydroxyisovaleryl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, CPT1A and 1 morecytosol

• CHEBI:63544Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 7 routes

• a 1-acyl-sn-glycero-3-phospho-L-serineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phospho-L-serine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosol

• a 1-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosol

• 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosol

• hexacosanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 9 routes

• a 2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosol

• a 2-acyl-sn-glycero-3-phospho-L-serineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = a 2-acyl-sn-glycero-3-phospho-L-serine + 1-O-acyl-N-(acetyl)-sphing-4-enine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosol

• UDP-alpha-D-galactoseReach from here →
  1. N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate
  2. N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate
  3. UDP-N-acetyl-alpha-D-glucosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-glucosamine(in) + UDP-alpha-D-galactose(out)

  Catalysed by PGM3, UAP1, SLC35A2inner side of the membrane, outer side of the membraneOne of 2 routes

• UDP-N-acetyl-alpha-D-galactosamineReach from here →
  1. N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate
  2. N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate
  3. UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine

  Catalysed by PGM3, UAP1, GALE

• (2E)-octadecenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by CEMP1, AMDHD2, GNPNAT1, CPT1A and 2 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 8 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosol

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosolOne of 4 routes

• 1-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosolOne of 3 routes

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosolOne of 3 routes

• 4-acetamidobutanalReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-acetylputrescine + H2O = putrescine + acetate
  3. N-Acetylputrescine:oxygen oxidoreductase(deaminating)(flavin-containing)

  Catalysed by CEMP1, AMDHD2, HDAC10, AOC2 and 4 morecytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 7 routes