(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

230 compounds within 3 steps: 7 in 1, 17 in 2, 206 in 3

Three steps

2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 1 more
2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 1 more
2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 1 more
2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 1 more
all-trans-retinyl tetradecanoateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA
Catalysed by TBXAS1, PTGS2, PTGIS, RETSAT and 1 more
S-methyl glutathioneReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)
Catalysed by GPX1, GPX2, GPX4, GSR and 1 more
L-cystine-bis-glycineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. cystine to cysteine conversion
3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine
Catalysed by GPX1, GPX2, GPX4, DPEP1 and 1 morecytosol
S-adenosylglutathioneReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)
Catalysed by GPX1, GPX2, GPX4, GSR and 1 more
acetylcholineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. transport of acetylcholine and GSH (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes
pyruvateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-cysteine hydrogen-sulfide-lyase (deaminating
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 morecytosolOne of 7 routes
(S)-malateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. (R)-malate + A = oxaloacetate + AH2
3. transport of malate and OAA (cytosol to mitochondria)
Catalysed by TBXAS1, PTGS2, PTGIS, D2HGDHmitochondrial matrix, cytosolOne of 7 routes
L-leucineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and leucine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 2 moreextracellular space, cytosolOne of 4 routes
CHEBI:15650Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and leukotriene E4 (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 9 morecytosol, extracellular spaceOne of 2 routes
all-trans-3-hydroxyretinolReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O
Catalysed by TBXAS1, PTGS2, PTGIS, RETSAT and 1 more
CHEBI:15699Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and homoserine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 3 routes
formateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)
Catalysed by TBXAS1, PTGS2, PTGIS, KDM1A and 2 more
bromideReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 25 morecytosolOne of 2 routes
CHEBI:15971Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and histidine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 2 routes
methanethiolReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
Catalysed by TBXAS1, PTGS2, PTGIS, KDM1A and 2 more
a halide anionReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
Catalysed by GPX1, GPX2, GPX4, GSR and 23 more
sulfateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
Catalysed by GPX1, GPX2, GPX4, TSTD1cytosolOne of 3 routes
11-cis-retinolReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-Retinol 11-cis-trans-isomerase
Catalysed by TBXAS1, PTGS2, PTGIS, RETSATcytosolOne of 2 routes
cob(II)alaminReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
lithocholic acidReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and lithocholate (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes
L-citrullineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of citrulline and cysteine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 2 routes
iodideReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 3 moreOne of 22 routes
L-valineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and valine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 3 routes
L-arginineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of arginine and cysteine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 6 routes
nitric oxideReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
protein polypeptide chainReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. PROTEIN_BS
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOScytosol
3'-deoxy-3',4'-didehydro-CTPReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
(S)-2-hydroxyglutarateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
CHEBI:16857Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and threonine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 4 routes
bilirubin IXalphaReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. transport of bilirubin and GSH (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes
taurolithocholateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and taurolithocholate (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes
L-isoleucineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and isoleucine (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 4 routes
CHEBI:17203Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and proline (cytosol to extracellular)
Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 3 routes
CHEBI:17208Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. glutathione:dehydroascorbate oxidoreductase
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 8 morecytosol
homocysteineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. Glutathione: 15-HPETE oxidoreductase
3. Formation of Homocystine
Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 8 morecytosol
5'-deoxyadenosineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 moreOne of 4 routes
sulfiteReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by GPX1, GPX2, GPX4, GSR and 1 moreOne of 6 routes
1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. Lecithin Retinol Acyltransferase
Catalysed by TBXAS1, PTGS2, PTGIS, RETSAT and 1 morecytosol
all-trans-retinyl hexadecanoateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
Catalysed by TBXAS1, PTGS2, PTGIS, RETSAT and 5 moreOne of 2 routes
3,3',5'-triiodo-L-thyronine sulfateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more
3,3'-diiodo-L-thyronineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 3 moreOne of 2 routes
3,3'-diiodo-L-thyronine sulfateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 moreOne of 2 routes
CHEBI:17724Reach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. dimethylglycine dehydrogenase (formaldehyde)
Catalysed by TBXAS1, PTGS2, PTGIS, KDM1A and 3 morecytosol
glycine betaineReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
2. choline + A = betaine aldehyde + AH2
3. p-cumic alcohol:NAD+ oxidoreductase
Catalysed by TBXAS1, PTGS2, PTGIS, CHDH and 1 morecytosolOne of 4 routes
urateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. urate(out) + glutathione(in) = urate(in) + glutathione(out)
Catalysed by GPX1, GPX2, GPX4, GSR and 1 moreinner side of the membrane, outer side of the membrane
methylarsonous acidReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
Catalysed by GPX1, GPX2, GPX4, GSR and 2 moreOne of 2 routes