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Reach

prostaglandin I2

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

248 compounds within 3 steps: 3 in 1, 54 in 2, 191 in 3

Does it reach a compound?

Two steps

L-cysteinylglycineReach from here →
1. transport of GSH and prostaglandin I2 (cytosol to extracellular)
2. glutathione gamma-glutamylaminopeptidase
Catalysed by SLCO2A1, GGTLC3, GGT1, GGT5 and 3 moreextracellular space, cytosolOne of 4 routes
(R)-noradrenalineReach from here →
1. transport of prostaglandin I2 (cytosol to extracellular)
2. transport of noradrenaline (cytosol to extracellular)
Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. transport of prostaglandin I2 (cytosol to extracellular)
2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes
ursodeoxycholateReach from here →
1. transport of prostaglandin I2 (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
prostaglandin G2Reach from here →
1. transport of prostaglandin I2 (cytosol to extracellular)
2. transport of prostaglandin G2 (cytosol to extracellular)
Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes
thromboxane B2Reach from here →
1. transport of prostaglandin I2 (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes
taurochenodeoxycholateReach from here →
1. transport of prostaglandin I2 (cytosol to extracellular)
2. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3extracellular space, cytosolOne of 4 routes

Three steps

(S)-carnitineReach from here →
Catalysed by SLCO1B1extracellular space, cytosol, endoplasmic reticulumOne of 2 routes
CHEBI:1146900Reach from here →
Catalysed by SLCO1B1, SLCO1A2

Page 2 of 5

, SLCO1B3

, AANAT

extracellular space, cytosol

One of 4 routes

2-hydroxybutyric acidReach from here →

Formation of Prostaglandin I2
Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
transport of 2-hydroxybutyrate and L-lactate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A6, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

transport of GSH and prostaglandin I2 (cytosol to extracellular)
Glutathione: 15-HPETE oxidoreductase
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 7 moreextracellular space, cytosol

AReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 1 moreextracellular space, cytosolOne of 8 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP3A4 and 5 moreextracellular space, cytosol

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP3A4 and 5 moreextracellular space, cytosol

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C8, CYP2C9, CYP2C19 and 2 moreextracellular space, cytosol

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP2C8, CYP2D6 and 4 moreextracellular space, cytosol

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C9, CYP2J2extracellular space, cytosol

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP2D6, CYP2C9 and 3 moreextracellular space, cytosol

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 4 routes

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1extracellular space, cytosol

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP3A4, CYP2C9extracellular space, cytosol

prostaglandin J2Reach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of prostaglandin D2 (cytosol to extracellular)
prostaglandin J2 hydrolysis

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

dopamine 3-O-sulfateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of dopamine (cytosol to extracellular)
dopamine + 3'-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1B1 and 3 moreextracellular space, cytosol

dopamine 4-O-sulfateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of dopamine (cytosol to extracellular)
Dopamine 4-O-Sulfotransferase

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 1 moreextracellular space, cytosolOne of 2 routes

hyocholateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
solute carrier organic anion transporter (chenodiol)
Chenodeoxycholic acid 6alpha-hydroxylase

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, CYP3A4extracellular space, cytosol

prostaglandin A2-S-(R)-glutathioneReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of prostaglandin A2 (cytosol to extracellular)
prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Catalysed by SLCO1B1, GSTA1, GSTM1extracellular space, cytosol

prostaglandin A2-S-(S)-glutathioneReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of prostaglandin A2 (cytosol to extracellular)
prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Catalysed by SLCO1B1, GSTP1, GSTM1extracellular space, cytosol

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by SLCO1B1, ALOX15extracellular space, cytosol

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by SLCO1B1, ALOX15extracellular space, cytosol

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by SLCO1B1, PM20D1extracellular space, cytosol

7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C9extracellular space, cytosol

chenodeoxycholoyl-24-O-(beta-D-glucuronate)Reach from here →

transport of prostaglandin I2 (cytosol to extracellular)
solute carrier organic anion transporter (chenodiol)
chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, UGT2A2 and 1 moreextracellular space, cytosol

acetoacetateReach from here →

Formation of Prostaglandin I2
Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
transport of acetoacetate and L-lactate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 1 morecytosol, extracellular spaceOne of 2 routes

16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosol

N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →

transport of GSH and prostaglandin I2 (cytosol to extracellular)
glutathione gamma-glutamylaminopeptidase
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

Catalysed by SLCO2A1, GGTLC3, GGT1, GGT5 and 4 moreextracellular space, cytosol

beta-D-glucosyl-(1->3)-O-chenodeoxycholateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
solute carrier organic anion transporter (chenodiol)
a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + a di-trans,poly-cis-dolichyl phosphate + H(+)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, GBA2extracellular space, cytosolOne of 2 routes

L-cystine-bis-glycineReach from here →

transport of GSH and prostaglandin I2 (cytosol to extracellular)
glutathione gamma-glutamylaminopeptidase
2 L-cysteinylglycine + [protein]-disulfide = L-cystine-bis-glycine + [protein]-dithiol

Catalysed by SLCO2A1, GGTLC3, GGT1, GGT5 and 4 moreextracellular space, cytosol

8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

Catalysed by SLCO1B1, FAAH, PM20D1extracellular space, cytosol

(15S)-15-hydroperoxy-prostaglandin E2Reach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of prostaglandin G2 (cytosol to extracellular)
prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2

Catalysed by SLCO1B1, PTGESextracellular space, cytosol

cholineReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of acetylcholine (cytosol to extracellular)
Acetylcholine aectylhydrolase

Catalysed by SLCO1B1, SLCO1B3, BCHE, ACHEextracellular space, cytosolOne of 5 routes

pyruvateReach from here →

transport of GSH and prostaglandin I2 (cytosol to extracellular)
cystine to cysteine conversion
L-cysteine hydrogen-sulfide-lyase (deaminating

Catalysed by SLCO2A1, CTHextracellular space, cytosolOne of 8 routes

all-trans-retinoic acidReach from here →

Formation of Prostaglandin I2
Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
transport of L-lactate and retinoate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

arachidonoyl-CoAReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
Arachidonate:CoA ligase (AMP-forming)

Catalysed by SLCO1B1, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosolOne of 3 routes

CHEBI:15519Reach from here →

transport of prostaglandin I2 (cytosol to extracellular)
solute carrier organic anion transporter (cholate)
Cholate:CoA ligase (AMP-forming)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC27A2 and 1 moreextracellular space, cytosol, endoplasmic reticulum

L-leucineReach from here →

transport of GSH and prostaglandin I2 (cytosol to extracellular)
cystine to cysteine conversion
transport of cysteine and leucine (cytosol to extracellular)

Catalysed by SLCO2A1, SLC7A9, SLC3A1extracellular space, cytosolOne of 3 routes

12(S)-HPETEReach from here →

transport of prostaglandin I2 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
arachidonate:oxygen 12-oxidoreductase

Catalysed by SLCO1B1, ALOX12extracellular space, cytosolOne of 4 routes