(S)-malyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

121 compounds within 3 steps: 1 in 1, 13 in 2, 107 in 3

Three steps

glutathioneReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and sulfite (cytosol to mitochondria)
3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by SUCLG1, SUCLA2, SLC25A10, TSTD1mitochondrial matrix, cytosolOne of 2 routes
L-alanineReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
Catalysed by SUCLG1, SUCLA2, ME2, ME3 and 1 moremitochondrial matrixOne of 18 routes
adenosine 5'-phosphosulfateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and sulfate (cytosol to mitochondria)
3. ATP:sulfate adenylyltransferase
Catalysed by SUCLG1, SUCLA2, SLC25A10, PAPSS1 and 1 moremitochondrial matrix, cytosolOne of 4 routes
glutathione disulfideReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and thiosulfate (cytosol to mitochondria)
3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by SUCLG1, SUCLA2, SLC25A10, TSTD1mitochondrial matrix, cytosol
trans-4-hydroxy-L-prolineReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate + a quinone = enol-oxaloacetate + a quinol
3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
Catalysed by SUCLG1, SUCLA2, SDHB, SDHA and 1 more
(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate hydro-lyase (fumarate-forming)
3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
Catalysed by SUCLG1, SUCLA2, FH, ADSLcytosolOne of 2 routes
kynurenateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
3. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
Catalysed by SUCLG1, SUCLA2, CLYBL, KYAT3 and 1 more
(3S)-citramalyl-CoAReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by SUCLG1, SUCLA2, ME2, ME3 and 1 moremitochondrial matrix
phosphoenolpyruvateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. Citrate Transport, Mitochondrial
3. phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)
Catalysed by SUCLG1, SUCLA2, SLC25A1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes
5-amino-2-oxopentanoateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by SUCLG1, SUCLA2, ME2, ME3 and 1 moremitochondrial matrixOne of 2 routes
S-sulfanylglutathioneReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and sulfite (cytosol to mitochondria)
3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
Catalysed by SUCLG1, SUCLA2, SLC25A10, ETHE1mitochondrial matrix, cytosolOne of 2 routes
L-prolineReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate + a quinone = enol-oxaloacetate + a quinol
3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
Catalysed by SUCLG1, SUCLA2, SDHB, SDHA and 2 more
estrone 3-sulfateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and sulfate (cytosol to mitochondria)
3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
Catalysed by SUCLG1, SUCLA2, SLC25A10, STSmitochondrial matrix, cytosol
(4R)-4-hydroxy-2-oxoglutarateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by SUCLG1, SUCLA2, ME2, ME3 and 1 moremitochondrial matrixOne of 2 routes
(5-hydroxyindol-3-yl)acetateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and sulfate (cytosol to mitochondria)
3. Transport of 5-Hydroxyindoleacetate
Catalysed by SUCLG1, SUCLA2, SLC25A10, SLC4A1mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes
ubiquinol-10Reach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and sulfite (cytosol to mitochondria)
3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate
Catalysed by SUCLG1, SUCLA2, SLC25A10, SQORmitochondrial matrix, cytosol
xanthurenateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
Catalysed by SUCLG1, SUCLA2, CLYBL, KYAT3 and 1 more
(4S)-4-hydroxy-2-oxoglutarateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by SUCLG1, SUCLA2, ME2, ME3 and 1 moremitochondrial matrixOne of 2 routes
beta-citrylglutamateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. Citrate Transport, Mitochondrial
3. citrate + L-glutamate + ATP = beta-citrylglutamate + ADP + phosphate + H(+)
Catalysed by SUCLG1, SUCLA2, SLC25A1, RIMKLBmitochondrial matrix, cytosol
3-methylmalateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
Catalysed by SUCLG1, SUCLA2, CLYBL
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by SUCLG1, SUCLA2, ME2, ME3 and 3 moremitochondrial matrix