succinyl-CoA

Three steps

• butanoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 6 moremitochondrial matrix, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 10 routes

• eicosanoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 13 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 14 routes

• tetradecanoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 12 routes

• octanoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. phytanate-CoA ligase

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2mitochondrial matrix, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 16 routes

• prostaglandin F2alphaReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

  Catalysed by SUGCT, ACOT8, ACOT4, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• a 1-acylglycerone 3-phosphateReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 3 more

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 3 moreOne of 2 routes

• an N-acylglycineReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 5 more

• sphing-4-enineReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 4 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 2 moremitochondrial matrix, cytosolOne of 3 routes

• L-methionineReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 4 more

• dehydroepiandrosterone 3-sulfateReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by SUGCT, ACOT8, ACOT4, SLC22A24 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 6 more

• L-alanineReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2mitochondrial matrix

• L-asparagineReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrix

• L,L-cystathionineReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrix

• kynurenateReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by SUGCT, ACOT8, ACOT4, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 15 more

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 2 moremitochondrial matrix, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 2 moremitochondrial matrix, cytosolOne of 4 routes

• a (2E)-enoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)
  3. a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O

  Catalysed by OXCT1, OXCT2, EHHADH, HADH and 3 more

• estrone 3-sulfateReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

  Catalysed by SUGCT, ACOT8, ACOT4, SLC22A24 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

  Catalysed by SUGCT, ACOT8, ACOT4, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• decanoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 6 moremitochondrial matrix, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrix, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 12 routes

• a cardiolipinReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 3 more

• 3-hydroxyisovaleryl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 2 moremitochondrial matrix, cytosol

• an all-trans-retinyl esterReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 6 more

• CHEBI:63544Reach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 8 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 6 more

• a triacyl-sn-glycerolReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 8 more

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 5 more

• hexacosanoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 6 routes

• tetracosanoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 11 routes

• docosanoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 10 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrix, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 9 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 7 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 6 routes