Compound

a (2E)-enoyl-CoA

An acyl-CoA(4−) oxoanion arising from deprotonation of the phosphate and diphosphate OH groups of any 2,3-trans-enoyl CoA; major species at pH 7.3.

Definition from ChEBI (CHEBI:58856), read 2026-09-23. CC BY 4.0.

CHEBI:58856ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound, anion
Formula: C24H33N7O17P3SR
Mass: 816.544 g/mol
Charge: -4
SMILES: [1*]/C=C/C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

5 entities

5 entities reached.

0 reported hops5 assembled from the scaffold

What the reference databases state

Statements

14 statements

14 statements · 1 reference database · Subject: a (2E)-enoyl-CoA · Sources: Rhea

Order

a (2E)-enoyl-CoA is converted to a (3R)-3-hydroxyacyl-CoACompoundRhea RHEA:26526Inferred only
a (3S)-3-hydroxyacyl-CoA is converted to a (2E)-enoyl-CoACompoundRhea RHEA:16105Inferred only
a (2E)-enoyl-CoA is converted to a (3S)-3-hydroxyacyl-CoACompoundRhea RHEA:16105Inferred only
a (2E)-enoyl-CoA is converted to a 2,3-saturated acyl-CoACompoundRhea RHEA:44700Inferred only
a 2,3-saturated acyl-CoA is converted to a (2E)-enoyl-CoACompoundRhea RHEA:18177Inferred only
a 2,3-saturated acyl-CoA is converted to a (2E)-enoyl-CoACompoundRhea RHEA:38959Inferred only
a 2,3-saturated acyl-CoA is converted to a (2E)-enoyl-CoACompoundRhea RHEA:44700Inferred only
a (2E)-enoyl-CoA is converted to a 2,3-saturated acyl-CoACompoundRhea RHEA:18177Inferred only
a (2E)-enoyl-CoA is converted to a 2,3-saturated acyl-CoACompoundRhea RHEA:33763Inferred only
a (2E)-enoyl-CoA is a substrate of ECHS1ProteinRhea RHEA:16105Inferred only
a (2E)-enoyl-CoA is a substrate of EHHADHProteinRhea RHEA:16105Inferred only
a (2E)-enoyl-CoA is a substrate of HADHAProteinRhea RHEA:16105Inferred only

Show the remaining 2

a (2E)-enoyl-CoA is a substrate of HSD17B4ProteinRhea RHEA:26526Inferred only
a (2E)-enoyl-CoA is a substrate of PECRProteinRhea RHEA:33763Inferred only

Reactions

8 reactions

a (3S)-3-hydroxyacyl-CoAa (2E)-enoyl-CoA+water
Catalysed by ECHS1 or HADHA or EHHADH
Reaction pageReversibleBalance undeterminable
Rhea RHEA:16105CC BY 4.0Reference data
a 2,3-saturated acyl-CoA+NAD(1-)a (2E)-enoyl-CoA+NADH(2-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:18177CC BY 4.0Reference data
a (3R)-3-hydroxyacyl-CoAa (2E)-enoyl-CoA+water
Catalysed by HSD17B4
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:26526CC BY 4.0Reference data
a (2E)-enoyl-CoA+NADPH(4-)+hydrona 2,3-saturated acyl-CoA+NADP(3-)
Catalysed by PECR
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33763CC BY 4.0Reference data
CHEBI:65102a (2E)-enoyl-CoA+water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:33767CC BY 4.0Reference data
a 2,3-saturated acyl-CoA+dioxygena (2E)-enoyl-CoA+hydrogen peroxide
Catalysed by ACOX3 or ACOX1 or ACOX2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:38959CC BY 4.0Reference data
a 2,3-saturated acyl-CoA+FAD(3-)+hydrona (2E)-enoyl-CoA+FADH2(2-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:44700CC BY 4.0Reference data
a 2,3-saturated acyl-CoA+oxidized [electron-transfer flavoprotein]+hydrona (2E)-enoyl-CoA+reduced [electron-transfer flavoprotein]
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:44704CC BY 4.0Reference data

Other names

5 names

Resolves to: a (2E)-enoyl-CoA

Also called: (2E)-enoyl-CoAs2,3-trans-enoyl coenzyme A(4-)2,3-trans-enoyl coenzyme A(4−)trans-2,3-didehydroacyl-CoA(4-)trans-2,3-didehydroacyl-CoA(4−)