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Reach

all-trans-13,14-dihydroretinol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

196 compounds within 3 steps: 2 in 1, 74 in 2, 120 in 3

Does it reach a compound?

Two steps

(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, TBXAS1, PTGS2, PTGIS
L-methionineReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by RETSAT, CDK5RAP1One of 4 routes
L-alanineReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by RETSAT, SCLYOne of 2 routes
an all-trans-retinyl esterReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. Lecithin Retinol Acyltransferase
Catalysed by RETSAT, LRATcytosolOne of 4 routes
a 2,3-saturated acyl-CoAReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
Catalysed by RETSAT, ACAD10
all-trans-retinyl 9Z-octadecenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
Catalysed by RETSAT, PNPLA4, PNPLA2
di-(9Z)-octadecenoylglycerolReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
Catalysed by RETSAT, PNPLA4, PNPLA2
2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by RETSAT, LRAT
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by RETSAT, PTGS1, PTGS2
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by RETSAT, PTGS1, PTGS2
9-cis-retinolReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. retinol binding protein (retinol)
Catalysed by RETSAT, RBP1, RBP2cytosolOne of 2 routes
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, PTGS2
thio-Mo-molybdopterinReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by RETSAT, MOCOS
2-glyceryl-prostaglandin H2Reach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by RETSAT, PTGS2
prostaglandin H1Reach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by RETSAT, PTGS2
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, PTGS2
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, PTGS2
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, PTGS2
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by RETSAT, PTGS2
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by RETSAT, PTGS2
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by RETSAT, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by RETSAT, PTGS2
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by RETSAT, PTGS2
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by RETSAT, PTGS2
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by RETSAT, PTGS1, PTGS2

Three steps

CHEBI:1146900Reach from here →
Catalysed by RETSAT, LRAT, LPCAT4, LPCAT3 and 2 morecytosolOne of 4 routes
N(omega)-methyl-L-arginineReach from here →

Page 2 of 4

Catalysed by RETSAT, SCLY, AGXT2

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by RETSAT, TBXAS1, PTGS2, PTGIS and 1 more

(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate

Catalysed by RETSAT, PTGS2, ALOX5

(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate

Catalysed by RETSAT, PTGS2, ALOX5

2,4-dinitrophenyl-S-glutathioneReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by RETSAT, DIO1, DIO2, SLCO1A2 and 1 moreextracellular space, cytosolOne of 4 routes

2-glyceryl-prostaglandin D2Reach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2

Catalysed by RETSAT, PTGS2, HPGDS

2-glyceryl-prostaglandin E2Reach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2

Catalysed by RETSAT, PTGS2, PTGES

11-cis-retinyl tetradecanoateReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
all-trans-Retinol 11-cis-trans-isomerase
11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

Catalysed by RETSAT, AWAT2cytosol

9-cis-retinyl tetradecanoateReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
retinol binding protein (retinol)
9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA

Catalysed by RETSAT, RBP1, RBP2, AWAT2cytosol

13-cis-retinyl tetradecanoateReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
retinol binding protein (retinol)
13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA

Catalysed by RETSAT, RBP1, RBP2, AWAT2cytosol

13-cis-retinyl hexadecanoateReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
retinol binding protein (retinol)
13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA

Catalysed by RETSAT, RBP1, RBP2, DGAT1cytosol

9-cis-retinyl hexadecanoateReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
retinol binding protein (retinol)
9-cis-retinol + hexadecanoyl-CoA = 9-cis-retinyl hexadecanoate + CoA

Catalysed by RETSAT, RBP1, RBP2, AWAT2cytosol

all-trans-4-hydroxyretinalReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-4-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O
NAD+[c] + all-trans-4-hydroxyretinol[c] = H+[c] + NADH[c] + all-trans-4-hydroxyretinal[c]

Catalysed by RETSAT, CYP27C1, ADH1BcytosolOne of 2 routes

pyruvateReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by RETSAT, SCLY, AGXT2mitochondrial matrixOne of 14 routes

all-trans-retinoic acidReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
retinol: NADP+ oxidoreductase
retinal:NAD+ oxidoreductase

Catalysed by RETSAT, DHRS3, RDH10, RDH11 and 6 morecytosolOne of 3 routes

CHEBI:15570Reach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
alanine racemase

Catalysed by RETSAT, SCLYcytosol

L-leucineReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
transport of alanine and leucine (cytosol to extracellular)

Catalysed by RETSAT, SCLY, SLC7A5extracellular space, cytosolOne of 10 routes

15(S)-HPETEReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Glutathione: 15-HPETE oxidoreductase

Catalysed by RETSAT, TBXAS1, PTGS2, PTGIS and 9 morecytosolOne of 2 routes

CHEBI:15699Reach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
transport of alanine and homoserine (cytosol to extracellular)

Catalysed by RETSAT, SCLY, SLC7A5extracellular space, cytosolOne of 6 routes

betaine aldehydeReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
choline + A = betaine aldehyde + AH2

Catalysed by RETSAT, CHDH

CHEBI:15971Reach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
transport of alanine and histidine (cytosol to extracellular)

Catalysed by RETSAT, SCLY, SLC7A6extracellular space, cytosolOne of 4 routes

11-cis-retinalReach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
retinol: NADP+ oxidoreductase
all-trans-Retinal 11-cis-trans-isomerase

Catalysed by RETSAT, DHRS3, RDH10, RDH11 and 5 morecytosolOne of 5 routes

1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
Lecithin Retinol Acyltransferase
Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

Catalysed by RETSAT, LRAT, LPCAT4, LPCAT3 and 2 morecytosol