a 1,2-diacyl-sn-glycerol

Two steps

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. ATP:acylglycerol 3-phosphotransferase

  Catalysed by LIPF, LIPC, PNLIP, CEL and 12 moreextracellular space, cytosolOne of 6 routes

• a cholesterol esterReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. Phosphatidylcholine:sterol O-acyltransferase

  Catalysed by CHPT1, CEPT1, LCATcytosolOne of 2 routes

• anilineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 3 morecytosol

• CHEBI:17312Reach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 1 morecytosolOne of 2 routes

• linoleic acidReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulumOne of 8 routes

• L-cysteineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 2 morecytosol, mitochondrial matrix

• a sphingomyelinReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. ceramide:phosphatidylcholine cholinephosphotransferase

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2cytosol, Golgi apparatusOne of 13 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 4 morecytosol, mitochondrial matrix

• glycerolReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

  Catalysed by LIPF, LIPC, PNLIP, CEL and 11 moreextracellular spaceOne of 2 routes

• CHEBI:17927Reach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 1 morecytosol

• a diacylglycerolReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 20 morecytosolOne of 2 routes

• dodecanoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• phosphatidyl-L-serineReach from here →
  1. CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
  2. L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase

  Catalysed by SELENOI, CEPT1, PTDSS2cytosolOne of 2 routes

• D-glucosyl-N-acylsphingosineReach from here →
  1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  2. UDP-glucose:N-acylsphingosine D-glucosyltransferase

  Catalysed by SGMS1, SGMS2, UGCGcytosolOne of 2 routes

• a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  2. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by SGMS1, SGMS2, UGT8One of 2 routes

• a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  2. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

  Catalysed by SGMS1, SGMS2, GBA1, GBA3One of 2 routes

• a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  2. an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by SGMS1, SGMS2, UGCGOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 9 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 9 morecytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 4 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• docosanoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• octadecanoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• alpha-linolenic acidReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• CHEBI:27540Reach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 7 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 17 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• CHEBI:28701Reach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 4 morecytosol, peroxisomeOne of 7 routes

• phosphocholineReach from here →
  1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by SGMS1, SGMS2, SMPD1

• tetradecanoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• (9Z)-octadecenoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• hexacosanoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• tetracosanoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• eicosanoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• (15Z)-tetracosenoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• (11Z)-eicosenoateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LPLextracellular spaceOne of 12 routes

• a fatty aldehydeReach from here →
  1. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)
  2. a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)

  Catalysed by DAGLB, ABHD11, DAGLA, ALDH3A2

• a sterol esterReach from here →
  1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  2. a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, LCAT

• a 1,3-diacylglycerolReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 3 morecytosolOne of 5 routes

• a 1,2-diacylglycerolReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 5 morecytosolOne of 6 routes

• taurineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 2 morecytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  2. a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline

  Catalysed by SGMS1, SGMS2, PTDSS1One of 2 routes

• glycineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 4 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 2 morecytosol, mitochondrial matrixOne of 2 routes