desmosterol

Three steps

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)Reach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate

  Catalysed by DHCR24, OSBP2, OSBPL2, PIP4P1 and 1 moreinner side of the membrane, outer side of the membrane

• spermidineReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by DHCR24, SOAT2, SOAT1, SAT1 and 1 moreendoplasmic reticulum, cytosolOne of 3 routes

• L-methionineReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by DHCR24, SOAT2, SOAT1, NAGSendoplasmic reticulum, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate

  Catalysed by DHCR24, OSBP, SYNJ2, SYNJ1 and 2 moreinner side of the membrane, outer side of the membrane

• L-alanineReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by DHCR24, SOAT2, SOAT1endoplasmic reticulum, mitochondrial matrix

• L-asparagineReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by DHCR24, SOAT2, SOAT1, NAGSendoplasmic reticulum, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by DHCR24, SOAT2, SOAT1, NAGSendoplasmic reticulum, mitochondrial matrix

• an acyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by DHCR24, SOAT2, SOAT1, ASAH1 and 3 moreendoplasmic reticulum, Golgi apparatusOne of 4 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by DHCR24, SOAT2, SOAT1, HADHA and 2 moreendoplasmic reticulum, mitochondrial matrixOne of 3 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Acyl-CoA:cholesterol O-acyltransferase
  3. Steryl-ester acylhydrolase

  Catalysed by DHCR24, SOAT2, SOAT1, CEL and 1 moreendoplasmic reticulum, lysosomeOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 1 moreendoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 1 moreendoplasmic reticulum, cytosolOne of 4 routes

• a 2,3-dehydroacyl-CoAReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by DHCR24, CH25H, ACAD10

• decanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, ACSM4 and 5 moreendoplasmic reticulum, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by DHCR24, SOAT2, SOAT1, CPT1A and 2 moreendoplasmic reticulum, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 11 routes

• Fe(II)-heme aReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

  Catalysed by DHCR24, CH25H, COX15

• 3-hydroxyisovaleryl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by DHCR24, SOAT2, SOAT1, CPT1A and 1 moreendoplasmic reticulum, cytosol

• CHEBI:63544Reach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 7 routes

• pregn-5-ene-3,20-dioneReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. cytochrome P450 (cholesterol)
  3. Pregnenolone:NAD+ 3-oxidoreductase

  Catalysed by DHCR24, CYP11A1, HSD3B1, HSD3B2endoplasmic reticulum, mitochondrial matrix, cytosolOne of 2 routes

• 4-methylpentan-1-olReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. cytochrome P450 (cholesterol)
  3. aldose reductase (isocaproic-aldehyde)

  Catalysed by DHCR24, CYP11A1, AKR1B10, AKR1B1endoplasmic reticulum, mitochondrial matrix, cytosolOne of 2 routes

• hexacosanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 5 routes

• a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine

  Catalysed by DHCR24, LCAT, ASPG

• tetracosanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 9 routes

• beta-D-glucosyl-N-octanoylsphing-4E-enineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside

  Catalysed by DHCR24, GBA1, GBA2One of 2 routes

• Mo-molybdopterinReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by DHCR24, CH25H, MOCOS

• (2E)-octadecenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by DHCR24, SOAT2, SOAT1, CPT1A and 2 moreendoplasmic reticulum, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 8 routes

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Acyl-CoA:cholesterol O-acyltransferase
  3. Steryl-ester acylhydrolase

  Catalysed by DHCR24, SOAT2, SOAT1, CEL and 1 moreendoplasmic reticulum, lysosomeOne of 2 routes

• 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine

  Catalysed by DHCR24, LCAT, PLA2G4C

• N-(hexadecanoyl)-sphing-4-enine-1-phosphateReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
  3. N-hexadecanoylsphing-4-enine + ATP = N-(hexadecanoyl)-sphing-4-enine-1-phosphate + ADP + H(+)

  Catalysed by DHCR24, GBA1, CERK

• 1,2-dihexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, PRDX6, LPCAT3 and 1 moreOne of 4 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT3

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT3, MBOAT1 and 3 moreOne of 2 routes

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT3, MBOAT2 and 1 more

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT3, MBOAT7One of 2 routes

• 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine

  Catalysed by DHCR24, LCAT, ASPG, PLA2G4C

• an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by DHCR24, GBA1, GBA2, SGMS1 and 2 more

• 1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + an N-acylsphing-4-enine
  3. 1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine

  Catalysed by DHCR24, GBA1, GBA2One of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 6 routes

• 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT3, MBOAT2

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 4 routes