CHEBI:17724

Three steps

• phenylacetylglycineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisomeOne of 3 routes

• CHEBI:28666Reach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. LTD4 hydrolysis

  Catalysed by PDPR, DMGDH, PIPOX, SARDHcytosol, peroxisome

• Gly-tRNA(Gly)Reach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome

• chlorine(.)Reach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 2 morecytosol, peroxisome, extracellular spaceOne of 3 routes

• glycocholateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by PDPR, DMGDH, SELENBP1cytosol

• oxalateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by PDPR, DMGDH, ALDH9A1, SLC26A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. alcohol dehydrogenase (formaldehyde)
  3. S-Formylglutathione hydrolase

  Catalysed by PDPR, DMGDH, ADH1C, ADH1A and 5 morecytosol

• 5-aminolevulinateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 2 morecytosol, peroxisome

• glycochenodeoxycholateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome

• glycochenodeoxycholic acidReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisomeOne of 11 routes

• glycolithocholic acidReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisomeOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome, mitochondrial matrix

• L-ornithineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisomeOne of 5 routes

• 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)
  3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)

  Catalysed by PDPR, DMGDH, ALDH9A1, ADI1cytosolOne of 2 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 2 morecytosol, peroxisome, mitochondrial matrix

• 7,8-dihydrofolateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. formaldehyde to 5,10-methylene-THF conversion
  3. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase

  Catalysed by PDPR, DMGDH, TYMScytosol

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 2 morecytosol, peroxisome

• (6R)-5,10-methenyltetrahydrofolateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. formaldehyde to 5,10-methylene-THF conversion
  3. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase

  Catalysed by PDPR, DMGDH, MTHFD2, MTHFD2Lcytosol, mitochondrial matrixOne of 4 routes

• an N-acylglycineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 3 morecytosol, peroxisome

• guanidinoacetateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisomeOne of 2 routes

• L-methionineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome, extracellular spaceOne of 5 routes

• L-tryptophanReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome, extracellular spaceOne of 5 routes

• glutathioneReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. alcohol dehydrogenase (formaldehyde)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by PDPR, DMGDH, ADH1C, ADH1A and 5 morecytosolOne of 2 routes

• L-alanineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. transport of alanine and glycine (cytosol to extracellular)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 3 morecytosol, peroxisome, extracellular spaceOne of 6 routes

• leukotriene C4Reach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. leukotriene C4 hydrolysis

  Catalysed by PDPR, DMGDH, PIPOX, SARDHcytosol, peroxisome

• L-asparagineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by PDPR, DMGDH, PIPOX, SARDHcytosol, peroxisome, extracellular spaceOne of 4 routes

• L-phenylalanineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome, extracellular spaceOne of 7 routes

• N,N-dimethylglycineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
  3. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]

  Catalysed by PDPR, DMGDH, PIPOXcytosol

• L-tyrosineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome

• N-formyl-L-kynurenineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)
  3. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)

  Catalysed by PDPR, DMGDH, ALDH9A1, AFMIDcytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisomeOne of 2 routes

• N-benzoylglycineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by PDPR, DMGDH, PIPOX, SARDHcytosol, peroxisome, mitochondrial matrixOne of 2 routes

• dTMPReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. formaldehyde to 5,10-methylene-THF conversion
  3. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase

  Catalysed by PDPR, DMGDH, TYMScytosol

• (2S)-2-aminobutanoateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome

• glycodeoxycholateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. Glycodeoxycholate amidohydrolase

  Catalysed by PDPR, DMGDH, PIPOX, SARDHcytosol, peroxisomeOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome

• N-eicosanoylglycinateReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome

• N-docosanoylglycineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome

• N-hexacosanoylglycineReach from here →
  1. dimethylglycine dehydrogenase (formaldehyde)
  2. sarcosine:oxygen oxidoreductase (demethylating)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by PDPR, DMGDH, PIPOX, SARDH and 1 morecytosol, peroxisome