CHEBI:16108

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

648 compounds within 3 steps: 9 in 1, 137 in 2, 502 in 3

Two steps

docosanoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (behenic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 9 routes
(2E)-octadecenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Carnitine O-Palmitoyltransferase
Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 3 routes
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (stearidonic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 8 routes
1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
1. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
Catalysed by GPD1, GPD1L, GPAT3, GPAT2 and 2 morecytosol
1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
1. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
2. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)
Catalysed by GPD1, GPD1L, GPAT3, GPAT2 and 2 morecytosol
a 1-O-alkylglycerone 3-phosphateReach from here →
1. Acyl-CoA:glycerone-phosphate O-acyltransferase
2. alkylglycerone phosphate synthase (acylglycerone-phosphate)
Catalysed by GNPAT, AGPScytosol, peroxisome
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (EPA)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 9 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (DPA)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 6 routes
(9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (linolenate)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 7 routes
(13Z)-docosenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 6 routes
(11Z)-eicosenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 7 routes
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 4 routes
(15Z)-tetracosenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (nervonic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 6 routes
(17Z)-hexacosenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (ximenic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 4 routes
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 7 routes
heptadecanoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 6 routes
(9Z)-heptadecenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes
1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
1. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
2. glycerol-3-phosphate 1-O-acyltransferase (linoleoyl-CoA)
Catalysed by GPD1, GPD1L, GPAT3, GPAT2 and 2 morecytosol
1-octadecanoyl-sn-glycero-3-phosphateReach from here →
1. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
2. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)
Catalysed by GPD1, GPD1L, GPAT3, GPAT2 and 2 morecytosol
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
1. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
2. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)
Catalysed by GPD1, GPD1L, GPAT3, GPAT2 and 2 morecytosol
nonadecanoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 3 routes
dodecanedioyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Activation of dodecanedioic acid
Catalysed by GNPATperoxisome, cytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Production of Sebacoylcarnitine
Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Production of Suberylcarnitine
Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by GNPATperoxisome, cytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosol
(13Z)-eicosenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by GNPAT, CRAT, CROTperoxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by GNPAT, ACAA1, HSD17B4, EHHADH and 1 moreperoxisome
hexadecanedioyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Production of Hexadecanedioylcarnitine
Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 2 routes
pristanoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. fatty-acid-CoA ligase
Catalysed by GNPAT, SLC27A2peroxisome, cytosolOne of 2 routes
1-O-hexadecylglycerone 3-phosphateReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
Catalysed by GNPAT, AGPSperoxisome
undecanoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 3 moreperoxisome, cytosolOne of 3 routes
hexadecanoateReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
Catalysed by GNPAT, AGPSperoxisomeOne of 2 routes
(5Z)-tetradecenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 8 routes
(3E)-decenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by GNPAT, ACADM, ECHS1, ACAA2 and 1 moreperoxisome, mitochondrial matrix
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by GNPAT, HADHA, ACAA2, HADHBperoxisome, mitochondrial matrix
(7Z)-hexadecenoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 8 routes
tricosanoyl-CoAReach from here →
1. glyceronephosphate O-acyltransferase (DHAP)
2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 4 routes

Three steps

2-hydroxybutyric acidReach from here →
Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes
N(omega)-methyl-L-arginineReach from here →