phosphatidylethanolamine

Three steps

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 5 moreendoplasmic reticulum, cytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Long-Chain-Fatty-Acid-Coa Ligase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, extracellular space, endoplasmic reticulumOne of 8 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 25 morecytosol, extracellular space

• butanoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 9 moreendoplasmic reticulum, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 12 routes

• glutaryl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 18 routes

• itaconyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (linoleate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 18 routes

• tetradecanoyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 15 routes

• octanoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 4 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 20 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular space

• phytanoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. phytanate-CoA ligase

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 3 moreendoplasmic reticulum, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, extracellular spaceOne of 21 routes

• prostaglandin H2Reach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. prostaglandin-endoperoxide synthase (arachidonate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular spaceOne of 3 routes

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 morecytosol, extracellular space

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 morecytosol, extracellular space

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• leukotriene A4Reach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Linoleate:oxygen 13-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular space

• (R)-2-hydroxyoctadecanoateReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• an N-acylsphing-4-enine 1-phosphateReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 2 moreendoplasmic reticulum

• sphing-4-enineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 7 moreendoplasmic reticulum, cytosol, Golgi apparatusOne of 6 routes

• sphinganineReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. an N-acylsphinganine + H2O = sphinganine + a fatty acid

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosolOne of 2 routes

• spermidineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 5 moreendoplasmic reticulum, cytosolOne of 3 routes

• L-methionineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 4 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 1 moreendoplasmic reticulumOne of 13 routes

• CDP-ethanolamineReach from here →
  1. L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
  2. ATP:ethanolamine O-phosphotransferase
  3. CTP:ethanolamine-phosphate cytidylyltransferase

  Catalysed by PTDSS2, CHKA, ETNK1, ETNK2 and 2 morecytosolOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphate(out) + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phosphate(in) + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)

  Catalysed by PIGF, PIGG, DGKI, DGKA and 10 moreendoplasmic reticulum, inner side of the membrane, outer side of the membraneOne of 2 routes

• sphinganine 1-phosphateReach from here →
  1. L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
  2. ATP:ethanolamine O-phosphotransferase
  3. Sphinganine-1-phosphate pamlmitaldehyde-lyase

  Catalysed by PTDSS2, CHKA, ETNK1, ETNK2 and 2 morecytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate

  Catalysed by PIGF, PIGG, DGKI, DGKA and 10 moreendoplasmic reticulum

• L-alanineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 3 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• a 1-O-alkyl-sn-glycero-3-phosphateReach from here →
  1. L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
  2. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
  3. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)

  Catalysed by PTDSS2, ENPP2cytosol

• L-asparagineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 4 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 4 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 30 moreendoplasmic reticulumOne of 14 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)Reach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 1 moreendoplasmic reticulum, inner side of the membrane, outer side of the membraneOne of 2 routes

• a CDP-1,2-diacyl-sn-glycerolReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate

  Catalysed by PIGF, PIGG, DGKI, DGKA and 12 moreendoplasmic reticulum

• an acyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. acyl-CoA pool formation and breakdown

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 14 morecytosol, extracellular spaceOne of 6 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 6 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 5 moreendoplasmic reticulum, cytosolOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 5 moreendoplasmic reticulum, cytosolOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular space

• (9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. linoleate:oxygen 9-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 14 morecytosol, extracellular space

• decanoyl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 9 moreendoplasmic reticulum, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Long-Chain-Fatty-Acid-Coa Ligase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, extracellular space, endoplasmic reticulumOne of 6 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. phosphatidylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular spaceOne of 16 routes

• a cardiolipinReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 1 moreendoplasmic reticulum

• an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by PIGF, PIGG, SGMS1, SGMS2 and 3 moreendoplasmic reticulumOne of 4 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. M4B Phosphoethanolaminyl Transferase, Endoplasmic Reticulum
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by PIGF, PIGG, DGAT1, MOGAT2 and 5 moreendoplasmic reticulum, cytosol