Proteins/UNIPROT:Q86VY4

TSPYL5

ProteinUNIPROT:Q86VY4

Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7..

Function from UniProtKB (Q86VY4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

12 statements

12 statements · 2 reference databases · Subject: TSPYL5 · Sources: gene ontology, Hetionet

Order

TSPYL5 covaries with AGBL5ProteinHetionet hetionet:covaries:60509-85453Inferred only
TSPYL5 covaries with TRERF1ProteinHetionet hetionet:covaries:55809-85453Inferred only
UBC interacts with TSPYL5ProteinHetionet hetionet:interacts:7316-85453Inferred only
USP7 interacts with TSPYL5ProteinHetionet hetionet:interacts:7874-85453Inferred only
TSPYL5 regulates positive regulation of cell population proliferationBiological processgene ontology Q86VY4|GO:0008284Inferred only
TSPYL5 regulates positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology Q86VY4|GO:0051897Inferred only
TSPYL5 regulates positive regulation of protein ubiquitinationBiological processgene ontology Q86VY4|GO:0031398Inferred only
ME2 decreases the expression of TSPYL5ProteinHetionet hetionet:regulates:4200-85453Inferred only
PEPD decreases the expression of TSPYL5ProteinHetionet hetionet:regulates:5184-85453Inferred only
PTEN increases the expression of TSPYL5ProteinHetionet hetionet:regulates:5728-85453Inferred only
SMARCB1 increases the expression of TSPYL5ProteinHetionet hetionet:regulates:6598-85453Inferred only
TOR1A decreases the expression of TSPYL5ProteinHetionet hetionet:regulates:1861-85453Inferred only

Other names

3 names

Resolves to: TSPYL5

Also called: KIAA1750Testis-specific Y-encoded-like protein 5TSPY-like protein 5

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