beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

101 compounds within 3 steps: 3 in 1, 18 in 2, 80 in 3

Three steps

(24S)-hydroxycholesterolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by GBA3, GBA1, CYP46A1
fatty acidReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. (10Z)-heptadecenoic acid formation
Catalysed by GBA3, ASAH1, ACER2, ASAH2cytosolOne of 4 routes
cholesteryl hexadecanoateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA
Catalysed by GBA3, GBA1, SOAT1
sphingosine 1-phosphateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. ATP:sphingosine 1-phosphotransferase
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 3 morecytosolOne of 2 routes
cholesteryl (9Z,12Z)-octadecadienoateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. (9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA
Catalysed by GBA3, GBA1, SOAT1One of 2 routes
25-hydroxycholesterolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
Catalysed by GBA3, GBA1, CH25HOne of 3 routes
N-octanoylsphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by GBA3, GBA1One of 2 routes
cholesteryl (9Z-octadecenoate)Reach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
Catalysed by GBA3, GBA1, SOAT2, SOAT1One of 2 routes
N-(acetyl)-sphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 1 moreOne of 2 routes
keto-D-fructoseReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. Aldehyde Reductase
3. keto-D-fructose + NADH + H(+) = D-sorbitol + NAD(+)
Catalysed by GBA3, SORDcytosol
(24R)-hydroxycholesterolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24R)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by GBA3, GBA1, CYP3A4
an N-acylsphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 6 moreOne of 6 routes
octadecanoyl-CoAReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. long-chain-fatty-acid-CoA ligase (stearate)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 7 morecytosolOne of 6 routes
(R)-2-hydroxyoctadecanoateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 1 more
dCMPReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. dATP:D-glucose 6-phosphotransferase
3. cytidine/uridine monophosphate kinase (dADP)
Catalysed by GBA3, HK1, HK2, HK3 and 2 morecytosolOne of 2 routes
dGMPReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. dATP:D-glucose 6-phosphotransferase
3. dADP to dATP conversion
Catalysed by GBA3, HK1, HK2, HK3 and 1 morecytosol, mitochondrial matrix
6-phospho-D-glucono-1,5-lactoneReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. ATP:D-glucose 6-phosphotransferase
3. D-glucose-6-phosphate:NADP+ 1-oxidoreductase
Catalysed by GBA3, HK1, GCK, HK2 and 3 morecytosol, endoplasmic reticulumOne of 6 routes
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)Reach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
Catalysed by GBA3, GBA1, OSBPinner side of the membrane, outer side of the membraneOne of 2 routes
1D-myo-inositol 3-phosphateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. ATP:D-glucose 6-phosphotransferase
3. 1D-myo-inositol-3-phosphate lyase (isomerizing)
Catalysed by GBA3, HK1, GCK, HK2 and 3 morecytosolOne of 2 routes
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)Reach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)
Catalysed by GBA3, GBA1, OSBP2, OSBPL2inner side of the membrane, outer side of the membraneOne of 2 routes
D-mannose 6-phosphateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
3. D-glucose 6-phosphate = D-mannose 6-phosphate
Catalysed by GBA3, ADPGK, GPI
sphing-4-enine 1-phosphateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. sphing-4-enine + ATP = sphing-4-enine 1-phosphate + ADP + H(+)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 2 more
dTMPReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. dATP:D-glucose 6-phosphotransferase
3. deoxythymidylate kinase (dADP)
Catalysed by GBA3, HK1, HK2, HK3 and 2 morecytosol, mitochondrial matrixOne of 2 routes
1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 1 more
(22R)-hydroxycholesterolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. 2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (22R)-hydroxycholesterol + 2 oxidized [adrenodoxin] + H2O
Catalysed by GBA3, GBA1, CYP11A1One of 2 routes
N-dodecanoylsphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 1 moreOne of 4 routes
N-tetradecanoylsphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate
Catalysed by GBA3, ASAH1, ACER2, ASAH2
N-hexadecanoylsphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 4 moreOne of 5 routes
N-eicosanoyl-sphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 2 more
N-tetracosanoyl-sphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 1 more
1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by GBA3, GBA1, LCATOne of 9 routes
N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 1 moreOne of 3 routes
N-(tetracosenoyl)-sphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. tetracosenoyl-CoA + sphing-4-enine = N-(tetracosenoyl)-sphing-4-enine + CoA + H(+)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 1 more
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 1 more
(25R)-cholest-5-ene-3beta,26-diolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. 2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (25R)-cholest-5-ene-3beta,26-diol + 2 oxidized [adrenodoxin] + H2O
Catalysed by GBA3, GBA1, CYP27A1
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 1 more
1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate(out) + cholesterol(in) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate(in) + cholesterol(out)
Catalysed by GBA3, GBA1, OSBPL2inner side of the membrane, outer side of the membraneOne of 2 routes
N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 2 moreOne of 4 routes
cholesteryl octadecanoateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. octadecanoyl-CoA + cholesterol = cholesteryl octadecanoate + CoA
Catalysed by GBA3, GBA1, SOAT1
cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
Catalysed by GBA3, GBA1, SOAT2, SOAT1One of 2 routes
sphinga-4E,14Z-dienineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
3. sphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O
Catalysed by GBA3, ASAH1, ACER2, ASAH2 and 1 more
beta-D-glucosyl-(1<->1)-sphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
Catalysed by GBA1, GBA2, ASAH1
cholesteryl (9Z)-hexadecenoateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
Catalysed by GBA3, GBA1, SOAT1
(9Z,12Z,15Z-octadecatrienoyl)-cholesterolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
Catalysed by GBA3, GBA1, SOAT2One of 2 routes
cholesteryl (8Z,11Z,14Z)-eicosatrienoateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (8Z,11Z,14Z)-eicosatrienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by GBA3, GBA1, LCAT
(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
Catalysed by GBA3, GBA1, SOAT2One of 2 routes
4beta-hydroxycholesterolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 4beta-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by GBA3, GBA1, CYP3A4
cholesteryl (5Z,8Z,11Z)-eicosatrienoateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z)-eicosatrienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by GBA3, GBA1, LCAT
(6Z,9Z,12Z-octadecatrienoyl)-cholesterolReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by GBA3, GBA1, LCAT
cholesteryl (11Z)-octadecenoateReach from here →
1. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA
Catalysed by GBA3, GBA1, SOAT1