9-cis-retinol

Three steps

• (5Z)-dodecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• docosanoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• octadecanoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• alpha-linolenic acidReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• CHEBI:27540Reach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 6 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 17 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• CHEBI:28701Reach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, peroxisomeOne of 7 routes

• phosphocholineReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 7 morecytosol

• tetradecanoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (9Z)-octadecenoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• hexacosanoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• tetracosanoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• an N-acylsphinganineReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. N-acylsphingosine amidohydrolase

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 11 morecytosol

• eicosanoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (15Z)-tetracosenoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (11Z)-eicosenoateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• all-trans-retinoateReach from here →
  1. Retinol Dehydrogenase (9-Cis, NADPH)
  2. 9-cis-retinal to retinal conversion
  3. all-trans-retinal + NAD(+) + H2O = all-trans-retinoate + NADH + 2 H(+)

  Catalysed by SDR16C5, RDH13, RDH11, RDH12 and 7 morecytosolOne of 2 routes

• 13-cis-retinalReach from here →
  1. Retinol Dehydrogenase (9-Cis, NADPH)
  2. 9-cis-retinal to retinal conversion
  3. 13-cis-retinal to retinal conversion

  Catalysed by SDR16C5, RDH13, RDH11, RDH12 and 2 morecytosolOne of 2 routes

• taurineReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosolOne of 2 routes

• glycineReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 2 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 6 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. phytanate-CoA ligase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 7 morecytosolOne of 15 routes

• sn-glycerol 3-phosphateReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 8 morecytosol

• sphing-4-enineReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 4 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 2 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol, mitochondrial matrix

• L-alanineReach from here →
  1. Lecithin Retinol Acyltransferase (9-Cis)
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol, mitochondrial matrix