1-octadecanoyl-sn-glycero-3-phosphate

Three steps

• (2E)-dodecenoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 morecytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 7 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by AGPAT3, PLA2G4A, SLC27A2, ACSL4 and 9 more

• butanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 morecytosol, mitochondrial matrixOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 9 routes

• glutaryl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 12 routes

• itaconyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 11 routes

• octanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. phytanate-CoA ligase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 morecytosol, mitochondrial matrixOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 12 morecytosol, mitochondrial matrixOne of 21 routes

• prostaglandin H2Reach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. prostaglandin-endoperoxide synthase (arachidonate)

  Catalysed by AGPAT3, PLA2G4A, PTGS1, PTGS2cytosolOne of 3 routes

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by AGPAT3, PLA2G4A, ALOX5, ALOX15 and 1 more

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by AGPAT3, PLA2G4A, ALOX15B, ALOX15 and 1 more

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by AGPAT3, PLA2G4A, ALOX5

• leukotriene A4Reach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O

  Catalysed by AGPAT3, PLA2G4A, ALOX5

• (R)-2-hydroxyoctadecanoateReach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + octadecanoate + H(+)
  3. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by AGPAT3, DDHD1, FA2H

• sn-glycerol 3-phosphateReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)

  Catalysed by LYPLA2, PNPLA7, PNPLA6cytosol

• sphing-4-enineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 morecytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 morecytosol, mitochondrial matrixOne of 3 routes

• L-methionineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrix

• L-alanineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 morecytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 morecytosol, mitochondrial matrix

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)

  Catalysed by DHRS7Bcytosol

• an acyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 morecytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 morecytosol, mitochondrial matrix, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 morecytosol, mitochondrial matrixOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by AGPAT3, PLA2G4A, FAAH, PM20D1

• decanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 morecytosol, mitochondrial matrixOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 morecytosol, mitochondrial matrix

• CHEBI:63544Reach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 7 routes

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. cytochrome P450 (arachidonate)

  Catalysed by AGPAT3, PLA2G4A, CYP4F8endoplasmic reticulumOne of 2 routes

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, GPAT3, LCLAT1, MBOAT2 and 5 morecytosol

• hexacosanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 10 routes

• docosanoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 morecytosol, mitochondrial matrixOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 morecytosol, mitochondrial matrixOne of 8 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2cytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2cytosol

• 1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2cytosol

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  2. 1-acylglycerol-3-phosphate pool formation and breakdown
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, AGPAT3cytosol

• N-octadecanoylsphing-4-enineReach from here →
  1. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + octadecanoate + H(+)
  3. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate

  Catalysed by AGPAT3, DDHD1, ASAH1, ACER2 and 1 more